Laparoscopic cholecystectomy (LC) is supposed to be a first line treatment for complicated bile stones and is regarded as the minimally invasive surgery. Objectives: To determine the levels of CRP as a measure of stress response after open and Laparoscopic cholecystectomy. Methods: A total of 120 patients of both genders aged 20 years or above with fever, abdominal pain, vomiting, nausea and anorexia with symptomatic gall stone were chosen. Laboratory tests, ultrasound and chest radiography were carried out to verify the diagnosis of cholecystectomy and prevent a negative abdomen exploration. The comparison of CRP levels between the two groups was done at 4, 8 and 24 hours. The values ​​of CRP in both procedures were compared with the t-test with P-0.000 taken as significant. Results: The patients mean age was 36.09 ± 8.10 years. There were 50 men and 70 women. Mean CRP was 7.20 ± 2.10 after 4 hours of laparoscopic cholecystectomy; however, after open cholecystectomy, it was 11.30 ± 1.80, CRP after 8 hours in LC was 13.50 ± 7.01 and 21.04 ± 2.14 after open cholecystectomy. The mean CRP levels in laparoscopic cholecystectomy after 24-hrs were 23.40 ± 7.92 and 34.81 ± 7.04 after open cholecystectomy. The most affected age group was 20-35 years in 39(32.5%) patients, 31-50 in 47(39.2%) and 51-65 in 34(28.3%) patients. This study did not find postoperative complications or mortality. Conclusions: CRP is a valuable marker in determining the response to stress in subjects with laparoscopic and open cholecystectomy.

Aim: The purpose of this study is to compare the incidence of wound infection in laparoscopic and open appendectomy. Study Design: A randomized, controlled study Place and Duration: In the Surgical department of Khalifa Gul Nawaz Medical Teaching Institute, Bannu and Ayub Teaching Hospital, Abbottabad for the duration from January 2021 to June 2021. Methods: In this study, 220 patients with the diagnosis of acute appendicitis were selected and divided randomly into two groups; OA group (open appendectomy) and LA group (laparoscopic) appendectomy. In both groups, the general anesthesia was given for appendectomy. The wound was examined on the 1st, 2nd and 3rd postoperative day, and then on the 7th and 14th day postoperatively and was scored conferring to the wound asepsis Score. The SSI and total wound asepsis score was calculated subsequently. Results: Total of 200 patients with acute appendicitis were selected. In laparoscopic appendectomy (LA); 22.0±7.85 years was the mean age and 24.12±9.08 years was the mean age in open appendectomy (OA) group. There were 70 men and 40 women in the LA group, and 50 men and 60 women in the OA group. The LA group has M:F ratio of 1.9: 1 in the and 1: 1.3 in the OA group. While 108 patients had no complications and surgical site infection were noticed in two patients only in the LA group, 98 patients in the OA group recovered and surgical site infection were seen in 12 patients. Conclusion: Laparoscopic appendectomy is a safer and better choice than open appendectomy which decreases postoperative complications significantly such as wound infections. Keywords: Open appendectomy, Laparoscopic appendectomy, Acute appendicitis and Surgical site infection.