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Introduction The consumption of health‐promoting products such as oil seeds may improve human health and prevent certain diseases. Carvi seeds have the potential to produce oil with nutritional and functional properties rich in active compounds. Objective To extract bioactive lipids from Carum carvi seeds using green methodologies. Material and methods Supercritical‐carbon dioxide (Sc‐CO2) and ethanol as co‐solvent and bio‐based solvent 2‐methyltetrahydrofuran (MeTHF) were used to extract the oil from Carum carvi. The yield, the chemical composition, as well as antioxidant and anti‐inflammatory activities of green extracted oils were investigated and compared to those obtained with conventional methods (hexane and Folch system). Results MeTHF extraction gave higher oil yield than that obtained by hexane. Fatty acids composition of the two obtained green extracted oils was similar to conventional extracted ones where petroselinic (39–43%), linoleic (29–31%) and oleic (19–21%) acids were the major compounds. Furthermore, MeTHF and Sc‐CO2 green extracted oils were enriched of bioactive compounds including sterols (5.4 and 7.3 mg/g oil) and total polyphenols (9.3 and 7.6 mg GAE/g oil) which were correlated to enhanced antiradical capacity. Moreover, the green extracted oils exhibited high anti‐inflammatory capacity inhibiting nitric oxide (NO) release in lipopolysaccharide (LPS)‐induced RAW 264.7 macrophages with IC50 values of 28 and 24 μg/mL. Conclusion Green solvents are a good alternative to petroleum solvents to recover oil from carvi seeds with high amount of nutritionally important fatty acids, along with significant antioxidant and anti‐inflammatory potential.

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This study assesses, qualitatively and quantitatively, the performance of ten bio-based solvents to replace hexane for the extraction of oil from Pistacia lentiscus edible fruits. Solvent screening was achieved through theoretical approach using the COnductor-like Screening MOdel for Realistic Solvation (COSMO-RS) predictions and an experimental protocol based on GC-FID and HPTLC analysis. Unsupervised multivariate analyses were performed on GC-FID and HPTLC data. Experiments corroborated theoretical predictions indicating that MeTHF was the best alternative solvent to replace hexane. Moreover, the obtained extract exhibited a good anti-inflammatory activity, inhibiting by 91.9% NO release in RAW 264.7 macrophages. These findings highlighted the potential of green solvents especially MeTHF in lipid extraction and exhibited that P. lentiscus oil presents a potential anti-inflammatory property and great nutritional value, notably high amount of oleic and linoleic acid, thus encouraging its valorization in food, cosmetic or pharmaceutical industry.