Background: Diabetic Nephropathy is one of the serious and life perilous complications of diabetes mellitus. Prolong duration of diabetes, no proper care and management, poor glycemic control in diabetic nephropathy can lead to End Stage Renal Disease (ESRD). Objective: To assess the relation of serum uric acid & micro albuminuria in the patients of diabetes mellitus for early detection of diabetic nephropathy. Methodology: This cross-sectional study was conducted in the Department of Medicine, LUMHS Jamshoro, with a total of 80 diabetic patients as case study subjects and 80 non-diabetic healthy participants as controls. Random glucose was measured using the gluco oxidase technique, and serum uric acid was measured using the uricase enzyme method in a calorimeter. Immunoterbidimetory kit technique was used to calculate microalbuminuria. Results: The mean value of random blood sugar (RBS) in the control group was 135 ± 10.11  mg/dl, but RBS in the case study group was 224 ± 13.52 mg/dl, indicating that RBS in the case study group was extremely significant (P < 0.001). The mean serum uric acid level in the control group was 4.7 ± 0.6 mg/dl, while it was 6.6 ± 1.4 mg/dl in the case study group, which is highly significant (P <0.001) with correlation (r= 0.34). Albumin in urine in the control group was 10 .2 ± 1.78 mg/gm, while it was 54± 10.34mg/gm in the case study group, which is a significant (P< 0.05) increase in the case study group with correlation (r= 0.28).  In diabetics, serum uric acid and microalbuminuria show a positive connection. Conclusion: This study concluded that there is strong positive relation of serum uric acid and micro albuminuria in diabetic patients for the early detection of diabetic nephropathy.

Background: Hypertension is one of the leading cause of morbidity and mortality in all over the world as in developed and under developing countries. Hypertension mostly associated with other clinical chronic disorders like diabetes mellitus, hyperuricemia, dyslipidemia etc. The ACE inhibitors are a kind of antihypertensive drug that is widely using all over the world. ACE inhibitors lowers blood pressure, but also lower uric acid levels as well. Aims & Objectives: To evaluate the efficacy of ACE inhibitors alone and along with the folic acid on systolic & diastolic blood pressure & on serum uric acid level. Methodology: This case-control research was carried out at the Medicine Department with the help of the Department of Biochemistry at LUMHS Jamshoro and the PAQSJ Medical Institute in Gambat. A total of 200 mild to moderate hypertension individuals with hyperuricemia were chosen. They were divided into two groups: the control group was taken 10 mg of lisinopril, while the case study group received 10 mg of lisinopril with 0.8 mg of folic acid for 10 to 12 weeks. Results: The mean value of systolic B.P in control group after treatment was126 ± 4.9 (P<0.05) while in case study group after treatment was 118 ± 6.12 mmHg (P<0.05). Diastolic B.P in control group after treatment was 90 ± 4.76 mmHg while in case study group was 82.3 ± 3.66 mmHg (P<0.05). The serum uric acid level after treatment in control group was 6.7 ± 4.78 mg/dl while in case study group, it was 5.5 ± 5.11 mg/dl (P<0.001). Serum Folic acid levels after the treatment in control group was 12.31 ± 2.89 while in case study group it was 27.09 ± 3.47 nmol/L (P<0.001).  Conclusion: Folic acid enhances the effectiveness of an ACE inhibitor (lisinopril) and has a substantial influence in the lowering of serum uric acid as therapeutic agent  in the cases of  mild to moderate hypertension associated with hyperuricemia.