Giant cell tumour of the metacarpal bone is rare. We have encountered three cases during the last 30 years. Surgical treatment is difficult in such a critical site and is always associated with functional deformities and poor cosmesis. We have successfully treated two males and one female with lesions of the 1st, 2nd and 4th metacarpal bones using a Theratron-60 telecobalt machine. The radiation dose delivered was 50-55 Gy over 4.5-5 weeks. The three patients all tolerated radiotherapy treatment well, though moderate radiation dermatitis (Grade II-III) was seen. The regression of tumour mass started after about 2 months of radiation therapy and complete regression occurred after several months. The pain subsided immediately. Long follow up of 7-11 years revealed no signs of local recurrence, distant metastasis or radiation induced malignancy. The results of radiation therapy are excellent in terms of functional integrity and cosmesis.

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Accurate gestational age estimation improves other and foetal care. Most commonly employed fetal parameters for estimation of gestational age, intrauterine growth and fetal weight are biparietal diameter (BPD), head circumference (HC), abdominal circumference (AC) and femur diaphysis length (FL). The objective of the present study was to evaluate the correlation of BPD and FL with gestational age in the population of Chhattisgarh state of India. In present study, 380 pregnant women of second and third trimester of pregnancy with known last menstrual period (LMP) had undergone routine ultrasonography for evaluation of Biparietal Diameter and Foetal Length. Biparietal Diameter and Foetal length was noted and correlation with gestational age was calculated. We observed a total of 158 cases in 2nd trimester and 220 cases were in 3rd trimester of pregnancy and they were aged between 18 and 35 years (two cases excluded). Mean of Biparietal diameter and FL observed was 73.1mm (±12.8 standard deviation and 11.6 standard error) and 56.2 (±0.63 standard deviation and 0.57 standard error) respectively. There was a strong positive correlation between gestational age and BPD (0.980). Correlation was maximum between 20 to 24 weeks of gestation (r=0.987) and minimum between 35 to 38 weeks of gestation (r=0.947). Ultrasonographic measurements of BPD and FL corelates with gestational age in second and third trimester (r value 0.980, 0.987 for, BPD and FL respectively). Correlation between Biparietal Diameter (BPD) and Gestational age consequently decreases according to gestation age from 20 weeks to 38 weeks. Correlation is maximum between.

Cervical carcinogenesis is a multi-step process associated with refractory infection by high-risk human papillomavirus (HPV) types. Only a minority of HPV infected women develop cervical intraepithelial neoplasia (CIN) or cervical cancer, indicating that HPV infection is not the sole risk factor to induce cervical cancer. The present study aimed to identify the association of toll like receptor 9 (TLR9) (2848C>T; rs352140) single neucleotide polymorphism (SNP) with cervical cancer in East Indian women. Study subjects comprised 71 women with histologically proven cervical cancer, and 100 women with benign cervical lesions. The case group included HPV 16 +ve subjects with malignancy. Among subjects with benign lesions, 43 were HPV 16 +ve (intermediate group) and 57 were HPV –ve (control group). TLR9 genotyping was performed using PCR RFLP. TLR9 expression was analyzed using real time PCR. For the C2848T polymorphism of TLR9, the TT genotype and the T allele frequency were significantly increased in the case group compared to those in the control group and the intermediate group. Our study suggests that the TLR9 C2848T polymorphism may be a genetic risk factor for cervical cancer and the progression from HPV infection to cervical cancer.