No abstract

No abstract

Objective: To Formulate and Evaluate bi-layered tablet of Divalproex Sodium. Method: Divalproex sodium is broad-spectrum anticonvulsant. It increases the availability of gammaamino butyric acid (GABA), an inhibitory neurotransmitter, The bilayer tablet of Divalproex sodium were prepared by using sodium starch glycolate, croscarmellose sodium, lactose, microcrystalline cellulose, polyvinyl pyrrolidone, magnesium stearate, talc, hydroxyl propyl methyl cellulose, as Excipents using wet granulation by using different Superdisintegrants. Result: In the present work, formulation and evaluation of bi-layered tablet of Divalproex sodium was carried out. In the project, different formulations of immediate release and sustained release layer have been prepared separately. From above formulations best formulation of each immediate and sustained release layers were selected according to the dissolution profile and bi-layered tablet were prepared. Conclusion:In the present work bi-layered tablet of Divalproex sodium were prepared by wet granulation method, using super disintegrants such as sodium starch glycolate and croscarmellose for immediate release layer and polymer like HPMC K4M and HPMC K100M for sustained release layer. Best formulations of each layer were selected for bi-layered tablet and bi-layered tablet were prepared. Bi-layered tablet of Divalproex sodium were subjected to hardness, weight variation, friability, drug content uniformity, in vitro drug release and drug polymer interaction.

No abstract

No abstract