Background: Subunit a of the V-ATPase is thought to contribute to proton-conducting hemichannels within the integral V 0 domain.
Results:We have identified transport-important residues and further defined the topology of subunit a. Conclusion: We propose a model for the proton-conducting hemichannels in V 0 . Significance: This represents the first proposed mechanism for proton transport through the V-ATPase.
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