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We investigated the effects of administration of Bifidobacterium prepara tions and commercially available Bifidus Yogurt on infantile intractable diarrhea. Fifteen patients with intractable diarrhea were treated from 1982 to 1985. These patients (11 boys and 4 girls) ranged in age from 1 month to 15 years (mean 2.5 years) and received antibiotic therapy for the treatment of such diseases as septicemia and respiratory tract infections. During treatment, waterly diarrhea appeared and lasted for 1 to 10 weeks (mean 25 days) with deterioration of the general condition. Conservative therapy such as diet control, infusion and drug therapy could not cure the diarrhea. The antibiotics used included cephems, penicillins and aminoglycocides. In most cases, abnormal microflora was ob served: Candida or Enterococcus often predominated with a marked decrease of anaerobes and aerobes in the stool flora. During the disease, we could not detect any pathogens or toxins responsible for the diarrhea. In all patients, the stool frequency and appearance were dramatically improved within 3 to 7 days after oral administration of Bifidobacterium preparations of bifidus yogurt. The intestinal microflora of all subjects also became normal with predominance of resident Bifidobacterium or administered B. breve.

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