A three-component thioamination reaction has been developed in the presence of phenyliodonium (III) diacetate (PIDA) leading to the formation of a thioaminated products. This catalytic approach represents a method for the metal-free thioamination of 1,4-naphthoquinone. It was observed that maleimides also work smoothly under this metal-free reaction condition. This present method implies the oxidative coupling reaction through a one-step process with the generation of CÀ N and CÀ S bonds. Various aromatic and aliphatic thiols and amines provided the corresponding thioaminated compounds in 62-88% yields. A plausible reaction pathway has been predicted according to few control experiments.

Lewis acidity plays a key role in the catalytic activity of lead ion (PbII) in the hydrolysis of glucose in solution under harsh synthetic conditions. We report a number of structurally similar d-gluconamide amphiphiles as functional organic ligands with active an −NH center capable of coordinating PbII (viz., PbII–N–C) in basic condition to enhance the catalytic efficiency through the scheme of molecular architectonics. Amphiphiles with different hydrophobic unit form assembly–architectures with a varying second coordination sphere around the active metal ion center. As a result, the active PbII center in each architecture exhibits substantially different efficiency toward catalyzing the glucose hydrolysis under ambient temperature. The catalytic performance of the dynamic and reversible gluconamide-PbII assembly–architectures are highly dependent on their chemical environments in solution. Further, the active PbII center of gluconamide-PbII complex in the assembly architecture and dispersed states exhibits distinct outcomes with the former being a superior catalyst than the latter as well as PbII alone. The current study demonstrates the potential of molecular architectonics that relies on the hydrophobic units of designer functional amphiphiles to enrich surface electron density with enhanced σ-donation ability through space which substantially improves the catalytic efficiency of PbII toward glucose hydrolysis at ambient temperature.

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Reaction of α, β‐unsaturated ketone (chalcone) and secondary amine leads to direct diamination of chalcone by dehydrogenation and forming two C−N bonds. This diamination reaction of chalcones with morpholine has been carried out through two effective protocols. The use of N‐iodosuccinimide (NIS) in tetrahydrofuran solvent in one strategy, while the combination of NH2OH ⋅ HCl and NaIO4 in dichloromethane solvent in another are very effective and work at room temperature. No other additives are required for this conversion. Mild and metal free conditions, simple operation technique, good to excellent yields are the notable advantages of both these protocols.

1-Butane sulfonic acid-3-methylimidazolium tosylate, [BSMIM]OTs, is a remarkable catalyst for the cascade synthesis of coumarin-functionalized indole derivatives via tandem cyclization reaction of aniline, phenylglyoxal monohydrate. This reaction possibly proceeds through...