Background: Streptococcus pneumonia had many serious serovars for which the vaccination was not yet developed, immunocompromised patients and patients with splenectomy were more susceptible to infection and sepsis by these organisms.Case presentation: We describe septic shock syndrome patient, who is diabetic with splenectomy, whose sepsis is caused by streptococcus pneumonia. The patient had a pneumococcal vaccination after having a splenectomy due to abdominal trauma five years ago. Strain 4 of streptococcus pneumonia caused the patient's septic shock. Results: Patient condition improved after 4 weeks of treatment with antibiotics, thrombolytic, renal replacement therapy and discharged in a good condition, no surgical procedures were needed apart of skin debridement of necrotized tissues. Conclusion: This instance demonstrates the necessity of considering illnesses caused by bacteria that patients have been immunized against when making a differential diagnosis because there are so many serovars present. Even though vaccine development has increased the development of vaccination for S. pneumonia serovars from 7 to 23 in the recent years, there is still a need for novel vaccines that can offer more generalized immunity against other serovars.