Revista da Sociedade Brasileira de Medicina Tropical 46(6):765-768, Nov-Dec, 2013http://dx.doi. org/10.1590/0037-8682-1716-2013 Dengue infection in children and adolescents: Clinical profi le in a reference hospital in northeast Brazil ABSTRACT Introduction:This study aimed to describe the clinical spectrum of dengue in children and adolescents from a hyperendemic region who were admitted for hospitalization. Methods: A retrospective study was conducted on patients diagnosed with dengue infection upon admission to a reference center in Fortaleza, Brazil. Results: Of the 84 patients included, 42 underwent confi rmatory testing. The main symptoms were fever, abdominal pain and vomiting. The median level of serum aspartate aminotransferase was 143.5±128mg/dL. Conclusions: A peculiar clinical profi le was evident among children and adolescents with dengue infection in a reference center in northeast Brazil, including gastrointestinal symptoms and liver involvement.