Although Central Giant Cell Granuloma (CGCG) is a benign tumor of the jaw and aneurysmal bone cyst seen in children, its aggressive behavior causes extensive loss of hard tissue requiring wide excision and extensive rehabilitation. We report a rare case of concomitant CGCG and aneurysmal bone cyst in a two-year-old male child, involving the coronoid and condylar process. Young age, large tumor, its aggressive nature, and future growth of orofacial region pose a significant challenge in the management of such conditions. For a successful outcome, the systematic approach to the presurgical evaluation and appropriate treatment planning is essential for such conditions.

Background: To determine X-ray repair cross-complementing 1 gene (XRCC-1) Arg194Trp polymorphism as bio-predictor for clinical outcome in advanced laryngeal squamous cell carcinoma undergoing cisplatin-based chemoradiation (CRT). Methods: A total of 150 patients were enrolled in this prospective study.XRCC-1 Arg194Trp genotyping categorized patients as wild (C/C) and polymorphic (C/T or T/T). The primary endpoint was to assess acute radiationinduced toxicity (ARIT).Results: A significant correlation of skin (P-.04) and oral mucosal ARIT (P-.01) was noticed in the XRCC-1 polymorphic variant. A higher treatment response was noted in the polymorphic variant, and it shows a trend toward significance (P-.08). With 33 months of median follow-up, 2-year progression-free survival (PFS) and overall survival (OS) of wild vs polymorphic variant were 34.6% vs 46.9% (P-.066) and 50.6% vs 62.2% (P-.12).Conclusion: XRCC-1 polymorphic variants have significantly higher grade of >2 ARIT and may have improved trend for treatment response and PFS. K E Y W O R D Scisplatin-based chemoradiation, locally advanced laryngeal squamous cell cancer, polymerase chain reaction, single nucleotide polymorphism, X-ray repair cross-complementing 1 gene | INTRODUCTIONThe incidence rate of head and neck squamous cell cancer (HNSCC) worldwide is approximately 0.83 million cases per year. In India, HNSCC incidence is about 0.19 million cases per year. Laryngeal cancer is reported to be nearly 21% and 14% of all HNSCC worldwide and India. 1 Squamous cell carcinoma is the most commonly diagnosed variant in laryngeal cancer, and 40% of these cases present with advanced stage. 2 Laryngeal cancer has a composite etiology, and the risk is increased by factors such as alcohol drinking, smoking, and tobacco chewing, and the metabolites produced by these factors cause a surge in DNA strand interruption. 3,4

BackgroundDental caries is a chronic disease among children and there is need for studies assessing the caries risk factors using saliva. This study aimed to evaluate the association of salivary soluble CD14 and dental caries in young children.Material and MethodsA cross-sectional study was done among 300, 3-6 year old school children of Udupi district. A total of 40 children who were caries free, with no past systemic illness or craniofacial anomalies and 40 children with dental caries with no history of dental treatment for caries, with no past systemic illness or craniofacial anomalies were included in control and test groups respectively. Salivary CD14 was evaluated using ELISA test.ResultsThe mean salivary soluble CD14 concentration was significantly higher in caries free (1.34±0.35 µg/ml) children than caries experienced (0.54±0.36 µg/ml) (p<0.001). There was significant strong negative correlation between number of decayed teeth and soluble salivary CD14 (r = -0.868, P< 0.001) among all the children. Similarly, sub-group analysis of caries experienced children also showed significant strong negative correlation between number of decayed teeth and soluble salivary CD14 (r = -0.774, P<0.001).ConclusionsResults obtained in our study suggested that salivary CD14 can be a indicator of dental caries in young children. Key words:Caries, CD14, Children, Saliva.

Culture results of a properly collected tracheal aspirate should be taken into consideration along with Centre for Disease Control and Prevention (CDC's) diagnostic criteria to maximise the diagnosis of VAP.

Introduction. Glass ionomer cements (GICs) are commonly used for cementation of indirect restorations. However, one of their main drawbacks is their inferior mechanical properties. Aim. Compositional modification of conventional glass ionomer luting cements by incorporating two types of all-ceramic powders in varying concentrations and evaluation of their film thickness, setting time, and strength. Material & Methods. Experimental GICs were prepared by adding different concentrations of two all-ceramic powders (5%, 10, and 15% by weight) to the powder of the glass ionomer luting cements, and their setting time, film thickness, and compressive strength were determined. The Differential Scanning Calorimetry analysis was done to evaluate the kinetics of the setting reaction of the samples. The average particle size of the all-ceramic and glass ionomer powders was determined with the help of a particle size analyzer. Results. A significant increase in strength was observed in experimental GICs containing 10% all-ceramic powders. The experimental GICs with 5% all-ceramic powders showed no improvement in strength, whereas those containing 15% all-ceramic powders exhibited a marked decrease in strength. Setting time of all experimental GICs progressively increased with increasing concentration of all-ceramic powders. Film thickness of all experimental GICs was much higher than the recommended value for clinical application. Conclusion. 10% concentration of the two all-ceramic powders can be regarded as the optimal concentration for enhancing the glass ionomer luting cements’ strength. There was a significant increase in the setting time at this concentration, but it was within the limit specified by ISO 9917–1:2007 specifications for powder/liquid acid-base dental cements. Reducing the particle size of the all-ceramic powders may help in decreasing the film thickness, which is an essential parameter for the clinical performance of any luting cement.