Background As global temperatures continue to rise, species distribution modeling is a suitable tool for identifying rare and endangered species most at risk of extinction, along with tracking shifting geographical range. Methods The present study investigates the potential distribution of Swertia bimaculata in the Darjeeling-Sikkim region of Eastern Himalaya in current and future climate scenarios of GFDL-CM3 (Geophysical Fluid Dynamics Laboratory-Climate Model 3) for the year 2050 and year 2070 through MaxEnt presence data modeling. Two sets of variables were used for modeling current scenario. The models were evaluated using AUC (area under the curve) values and TSS (true skill statistic). Results Habitat assessment of the species shows low and sporadic distribution within the study area. A significant decrease is observed in the possible range of the species in the future climate scenario with the habitat decreasing from 869.48 to 0 km2. Resultant maps from the modeling process show significant upward shifting of the species range along the altitudinal gradient. Still, results should be taken with caution given the low number of occurrences used in the modeling. Conclusions The results thus highlight the vulnerability of the species towards extinction in the near future.

A novel alternative prospect to prevent bacterial infections without inhibiting the growth is to apply chemicals that inhibit quorum sensing mechanism of the pathogens. Antiquorum property of 61 medicinal plants was evaluated by the ability of their leaf extract(s) to inhibit production of pigment (violacein in Chromobacterium violaceum MTCC 2656, pyocyanin in Pseudomonas aeruginosa MTCC 2297) or swarming in P. aeruginosa MTCC 2297. The most prospective plants (for the development of quorum sensing inhibitor), showing inhibition of violacein production without affecting bacterial growth, were Astilbe rivularis, Fragaria nubicola and Osbeckia nepalensis.

Background: Carapichea ipecacuanha (Brot.) L. Andersson is the botanical source of Ipecac drug and contains major alkaloids emetine, cephaline that are pharmaceutically used against bronchitis associated with cough in children, severe diarrhea (amoebic dysentery) and also cancer. Ipecac serves as an expectorant to thin mucous and easy coughing. Low doses are used to enhance appetite and it is administered orally to cause vomiting after suspected poisoning. Materials and Methods: The review highlights the taxonomy, nomenclature, distribution, medicinal uses and major pharmacological activities including side effects of Ipecac drug reported in recent years consulting various published papers dealing with Ipecac. Results and Conclusion: The species is rarely distributed due to disturbances in their habitats in natural growing condition. Further studies are required to scientifically evaluate the traditional uses of this plant through extraction and identification of their active ingredients and the mechanisms and mode of action that would serve as a source of collective information on this plant.

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The present communication deals with the carbon dynamics in the Himalaya hotspot region. The Himalaya, a mountain range shared by Pakistan, India, Nepal, Bhutan and Myanmar, is one of the biologically richest regions in the world that play an important role as source and sink in global carbon cycle. The purpose of this paper was to review and provide available studies related to carbon sequestration in the Himalayas. The carbon in forest is stored in five different pools viz. above-ground biomass, below-ground biomass, litter, deadwood and soil organic carbon. Estimates of biomass, carbon stock and soil organic carbon contents by almost all forest types including agroforestry systems and plantations in the Himalaya hotspot have been documented in this communication. The net rate of carbon sequestrated by forest was reported to be 2.4 ±0.4 Pg C yr-1 on a global scale. The Indian Himalayan Region constitutes about 5.4 billion tonnes of C and sequesters about 65 million tonnes of C yr-1. We analysed more than 135 peer-reviewed journal articles related to biomass and carbon sequestration. The review identifies that the studies estimated 3697.05, 3898.10 and 4235.05 tonnes carbon per hectare for Western, Central and Eastern Himalayan region respectively. The research on the biomass/carbon estimation received attention as early as 1980s, but increased gradually after 2001. These findings would contribute to policy-makers with useful information for mitigation of CO2 emissions.