Over the past 2000 years, tuberculosis (TB) has killed more people than any other infectious disease. In 2021, TB claimed 1.6 million lives worldwide, making it the second leading cause...

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A simple strategy for the synthesis of 5‐substituted‐3‐methylcyclohex‐2‐en‐1‐ones by proline‐catalyzed five‐step domino reactions of acetone and aromatic aldehydes is reported. The starting materials are stirred in the presence of L‐proline for 24 h then heated to 45 °C for a further 4‐6 h. The method can also be changed to exclusively form α,β‐unsaturated methyl ketones with >99 % E‐selectivity by heating the mixture to 80 °C in the second stage.

A simple strategy is reported for the synthesis of chiral Nprotected morpholinone derivatives by a base (potassium carbonate)mediated cyclization reaction of N-protected α-amino acids with 1,2dibromoethane. The morpholinone derivatives are obtained in good yields and in enantiomerically pure forms.

A simple and efficient strategy for the synthesis of 6-substituted-2-pyrone derivatives, by BF3·OEt2 mediated one pot cyclization and keto-protection of δ-hydroxy-β-keto esters, obtained via regioselective addition of 1,3-dicarbonyl dianion of ethyl acetoacetate to aldehydes and ketones is described.