The objective: to study the M-cholinoblockers effect by urinary incontinence after the formation of an artificial bladder and to analyze the effectiveness of pharmacological correction on survival and quality of life. Materials and methods. 114 patients after radical cystectomy with the formation of a neobladder at various stages of the postoperative period involved in the study. The significant urinary incontinence of different degrees, which affected the patient’s quality of life, was determined in 27 (23.7%) persons who were included in solifenacin effect study group. To identify the degree of severity and the dynamics of recovery of the continence function, a questionnaire was conducted among patients who had urinary incontinence during the day and at night. With the help of a comprehensive study on the Delphis KT urodynamic unit, an analysis of urodynamic parameters in urinary incontinence was carried out. Results. After the formation of an artificial bladder, the patients had more stable daytime continence due to mental control over urination and understanding the need to urinate according to time. The situation was more complicated in patients with nocturnal urinary incontinence after radical cystectomy and the formation of an artificial bladder. However, after 2 weeks of treatment with solifenacin, patients had a significant improvement in the function of nocturnal urinary retention. After treatment with solifenacin patients had an improvement in daytime urinary retention by 37.2 % and nighttime urinary retention by 48.9 %. Two-week treatment with solifenacin significantly improved the patient’s quality of life and the dynamics of enterocystomanometry indicators, as evidenced by the results of control studies. The indicator of the subjective sensitivity level increased statistically significantly by 35.24 % compared to the group before treatment and amounted to 304.2±62.1 cm of water column (p≤0.05). The level of the first urge to urinate also increased reliably by 20.4 % – 458.2±81.0 cm of water column (p≤0.05). The level of urge to urinate was 636.1±92.8 ml (p≤0.05), which was statistically significantly higher by 17.5 % compared to patients who did not take solifenacin. Conclusions. The use of M-cholinoblockers in the correction of urinary incontinence in patients with an artificial urinary bladder due to the action on the smooth muscles of the intestines through parasympathetic innervation improves urodynamic indicators and the quality of life of the patients.

Bladder cancer accounts for 50–70% of all malignant diseases of genital urinary system and 4% of all oncological diseases. It is well known, that in Ukraine men have such pathology 4 times more often than women and, unfortunately, up to 22% of patients die within the first year after confirmed diagnosis. The basic criteria of treatment effectiveness of the patients with oncological diseases are not only the rate of their survival, but also their quality of life. One of the main types of treatment for muscle-invasive bladder cancer is radical cystectomy with different variants of urinary diversion. The morphological changes in the muscle layer of the neobladder can cause deviations in the regulations of its contractility. This evolution of the smooth muscle wall demonstrates the electrophysiological contractility features of the neobladder compared to the ileum. The objective: to analyze the pathogenetic moments of the smooth muscle contractility regulation of the artificial bladder. Materials and methods. The experimental study on female mini-pigs aged 16–19 months, with weight 30–40 kg, the duration of the study was 12 months. The experimental model of the artificial bladder was performed by cystectomy in animals following by the terminal ileum of the neocyst, its anastomosis with the ureters, urethra under the anesthesia. After the forming of the neobladder the experimental animals had anesthesia with tiopental, and the neocyst and part of the ileum were removed, in one year. The experiments were carried put on the 18 pairs of specimens: isolated strips of the small intestine of mini-pigs and strips of the wall of the artificial bladder. Results. It was determined that spontaneous activity of the ileum and neobladder smooth muscles in 12 months has different indices. During the experiment the spontaneous activities of longitudinal smooth muscles (SM) of the ileum and neobladder were compared. It was determined that the spontaneous contractions of the neobladder SM are significantly different from the strip ileum contraction in control by larger amplitude and the complex shape. Conclusions. The hypertrophic growth of smooth muscles (SM) is a complex dynamic phenomenon that includes not only the structural changes, but also the complex physiological processes, namely aimed at transforming the part of the intestines to perform a new function of the urinary reservoir. The artificial bladder performs the functions of the natural bladder, there by making the life easier for a patient. The study of smooth muscle contractive activity regulation mechanisms under the influence of nervous and humoral systems will allow to expand the methods of its correction.