Inflammation is often associated with the development and progression of cancer. The cells responsible for cancer-associated inflammation are genetically stable and thus are not subjected to rapid emergence of drug resistance; therefore, the targeting of inflammation represents an attractive strategy both for cancer prevention and for cancer therapy. Tumor-extrinsic inflammation is caused by many factors, including bacterial and viral infections, autoimmune diseases, obesity, tobacco smoking, asbestos exposure, and excessive alcohol consumption, all of which increase cancer risk and stimulate malignant progression. In contrast, cancer-intrinsic or cancer-elicited inflammation can be triggered by cancer-initiating mutations and can contribute to malignant progression through the recruitment and activation of inflammatory cells. Both extrinsic and intrinsic inflammations can result in immunosuppression, thereby providing a preferred background for tumor development. The current review provides a link between inflammation and cancer development.

Background and Objective: This study was aimed to evaluate the collagen fibers qualitatively and its correlation with microvascular density in various grades of oral submucous fibrosis (OSMF). Material and Methods: The present study comprised of total 40 cases of oral submucous fibrosis. Picrosirius red staining was done on all the specimens’ sections. They were analyzed for the colour and orientation of collagen fibers. Morphometric measurements were done using image analysis on immunohistochemical stained sections for Factor VIII-related antigen and analyzed for microvascular density. Results: Picrosirius red polarizing microscopy results revealed that there was a shift in the colour of collagen fibers from greenish yellow to orange red and red colour as the severity of the oral submucous fibrosis increased. The collagen fibers showed mixed orientation in early oral submucous fibrosis and parallel orientation in advanced oral submucous fibrosis. There was a significant decrease in microvascular density from early to advanced oral submucous fibrosis. Conclusion: The change in the colours and orientation of collagen fibers in early and advanced oral submucous fibrosis could be attributed to the fibre thickness, type of collagen, alignment and packing, cross-linking of the fibers and the section thickness. However, in advanced cases the vascularity is reduced which may predispose to epithelial atrophy and subsequent malignant changes.

Papillon-Lefèvre syndrome (PLS) is a rare disorder characterized by palmar plantar hyperkeratosis and rapidly progressive periodontitis with loss of deciduous and permanent dentition at an early age. It is reported to occur in 1 to 4 individuals per million people. This case report presents highlighting features of the rare PLS in a 17-year old male who complained of discomfort while mastication and it was accompanied with symmetrical, sharply demarcated erythematous plaques involving the skin of the palms and soles, which extended to the finger joints, elbows, and knees. Along with the rough and dry skin, hyperhidrosis of lesion with a foul odor and transverse grooving of nails were noted. The past dental history revealed normal eruption of deciduous teeth followed by pre-mature mobility and shedding in 4-6 months. Permanent teeth also showed normal eruption and early shedding in the next 4-5 years. Complete edentulous maxillary and mandibular arches led to a decrease in alveolar bone and facial heights. There was no similar disorder in the patient’s family but family history revealed the consanguineous marriage of the patient’s parents.

Oral cavity harbours more than 700 species of micro-organisms. Imbalance in acidogenic and aciduric bacterial causes initiation of Dental caries whereas anaerobic bacteria lead to periodontal disease. Treatment of these diseases use of various chemicals which may have unpleasant taste, allergic reaction or toxicity even can cause financial burden. To overcome this, alternative therapeutical agents which are safer to oral tissues as well as economical.  Plants can be better alternative and they are used as Medicine since ages. Ayurveda and Chinese traditional medicine has mentioned the various medicinal properties of these plants. The use of plants / their products can be dated through old eras like use of neem bark or miswak for cleaning the teeth, use of clove oil for dental pain relief. In Ayurveda, methods like Dant Dhavani, Jivha Lekhana, Gandusha and Tissue regeneration therapies are recommended for oral health and involves use of plant or plant extract. Each Plant is the power house of the various chemicals known as phytochemicals which have numerous medicinal actions. Application of these phytochemicals in the dental science is the Phytodentistry. Phytodentistry can be expounded as the use of plants and their extract for the treatment or prevention of various dental diseases.

The main goal of pulp therapy in primary dentition is to preserve the primary tooth thus protecting future normal occlusion. Routinely, pulp debridement and canal shaping are done by manual H-files, K-files, Broach, etc. Manual instrumentation may be time- consuming, thus impacting the behaviour of the child negatively. Thus arises the need for alternate instrumentation which will reduce the time required for treatment with better treatment outcomes. In 1988, Walia et al. introduced Nickel-Titanium (Ni-Ti), which revolutionized the discipline of Endodontics. These Ni-Ti files have advantage of shape memory and super elasticity thus improving the canal preparation and resulting in better shaped canals. In 2002, for first time Barr et al reported the use of rotary Ni-Ti files for the therapeutic purpose during Pulpectomy procedure in pediatric patient. He observed better acceptance by pediatric patient and good quality obturation. Till 2016, pulpectomy procedures were accomplished by the combination of hand files and adult rotary files. Adult rotary files are designed according to the morphology for permanent teeth and adult jaw size, thus the use of adult rotary files are in primary teeth may result in lateral perforation due to softer dentine of roots of primary teeth and may cause discomfort to the child thus making child unco-operative. But in 2016, Ganesh et al., pioneered the specialization of Paediatric Endodontics with his invention of specially designed rotary files. Their shape was specially designated for application in tortuous canals of primary teeth. Presently, a variety of pediatric rotary files like Kedo-STM (India), Pro AF Baby GoldTM (India),PrimePedoTM (India), DXL-ProPedoTM (India), NeolixTM (France),Denco® Kids files (China) and, Sani® Kid rotary files (China). This review is an album of these newer files and clinical and in-vitro research on them.