No abstract

Whether or not the Free-Wilson and Hansch methods are compatible depends upon the functional relation connecting the independent variables of the two methods. This relation is often unknown.

The Free-Wilson equations are derived for the case of symmetrical substitution and are applied, in four modifications, to in vitro inhibitory activity of 77 organic disulfides against Histoplasma capsulatum. Substituent constants are listed to aid in the design of new inhibitory agents against this human pathogen (and perhaps other fungal organisms).

No abstract

Since Eo -2E2 equals the sum of monomeric species, one may calculate EO,app = Eo -2E2 and proceed as in the case at the simple monomer calculation (eq 2). The program for pH's at which E, EH, and E2 are significant calculates values of both [H]CH and K d . In the high p H limit (1 + [IIQ 4Kd [Eo] -2[&1 = Deoxyribonucleic Acid Replication.Abstract: Lowdin has proposed a mechanism, based on the stability of the DNA "replication plane," to explain the exclusion of rare tautomeric forms of nucleotide bases from double-stranded DNA. A quantitative theoretical test of this mechanism was carried out using a simple electrostatic model to compute the stability of replication planes. Atomic charges used in the model were obtained by adding T charges calculated by the Pariser-Parr-Pople method to u charges from Del Re calculations. The model does predict the proper degree of incorporation of adenine and thymine rare forms, but fails for the rare forms of guanine and cytosine. The model further predicts the ratio of bromouracil to thymine incorporation to be 0.2 in agreement with the experimental value of 0.23. ery early Watson and Crick' suggested that DNA