Ketone 8. A solution of 80 mg of ketone 7 in 10 mL of benzene was added over a 15-min period to a stirring suspension of 48 mg of potassium tert-butoxide in 5 mL of benzene under nitrogen at 60 6C and the mixture stirred at this temperature for an additional 30 min. It was poured into ice water and extracted with chloroform. The extract was washed with water, dried, and evaporated. Chromatography of the residue (60 mg) over neutral alumina and elution with 50:1 benzene-ethyl acetate yielded 48

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CEP-1347 (7) was prepared at even higher specific activity by the alkylation of precursor 6 with C 3 H 3 I.

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