No abstract

Wall remodeling associated with rapid luminal enlargement of collateral mesenteric arteries in rats was investigated 1 and 4 weeks after creation of a collateral pathway by ligating three to four sequential arteries. Paired observations were made of inner diameters of collateral and normal arteries in the same animals. Arterial blood flow was measured at the final observation. Sections of arteries were processed for morphological measurements. After 4 weeks, inner arterial diameter was increased more at the beginning (63 +/- 6%) than the end (25 +/- 9%) of the collateral pathway. At 1 and 4 weeks, respectively, cross-sectional areas of collateral relative to normal arteries were increased by 46 +/- 5% and 59 +/- 13% (lumen), 55 +/- 8% and 65 +/- 14% (media), and 89 +/- 18% and 60 +/- 31% (intima). The wall expansion during luminal enlargement resulted in a normal medial thickness:luminal radius relationship. At 1 week postligation, wall shear rate remained elevated and endothelial but not smooth muscle hyperplasia had occurred (intimal nuclei: 40 +/- 1.7 collateral versus 24 +/- 3.0 normal; medial nuclei: 42 +/- 6.8 collateral versus 37 +/- 2.1 normal). At 4 weeks, wall shear rate in collaterals was similar to normal arteries, and smooth muscle hyperplasia had taken place (medial nuclei: 84 +/- 9.4 collateral versus 44 +/- 4.7 normal). The data demonstrate that wall expansion associated with rapid luminal enlargement of these collaterals involves hyperplasia of both endothelial and smooth muscle cells; however, smooth muscle proliferation does not occur until after wall shear rate is reduced. The specific cellular adaptations that occur during collateral development may depend on the level of wall shear and shear-dependent modulation of endothelial growth factors.

We address the problem of interference aware routing in multi-radio infrastructure mesh networks wherein each mesh node is equipped with multiple radio interfaces and a subset of nodes serve as Internet gateways. We present a new interference aware routing metric -iAWARE that aids in finding paths that are better in terms of reduced interflow and intra-flow interference. We incorporate this metric and new support for multi-radio networks in the well known AODV routing protocol to design an enhanced AODV-MR routing protocol. We study the performance of our new routing metric by implementing it in our wireless testbed consisting of 12 mesh nodes. We show that iAWARE tracks changes in interfering traffic far better than existing well known link metrics such as ETT and IRU. We also demonstrate that our AODV-MR protocol delivers increased throughput in single radio and two radio mesh networks compared to similar protocol with WCETT and MIC routing metrics. We also show that in the case of two radio mesh networks, our metric achieves good intra-path channel diversity.