Diethyl ether was given before or after a single daily spatial discrimination trial in a water maze. Both C57BL/6J and DBA/2J mice made more errors than controls of these same strains when they were etherized after a trial, although the decremental effect on performance was more notable in the former strain. Pretrial etherization had no effect on errors, but mice etherized prior to each trial showed faster swimming times than control Ss. These data were discussed in terms of strain differences in ether-stimulated arousal or activity level.
Some problems inherent in administering inhalation anesthetics to small laboratory animals in studies of memory consolidation are discussed. A simple and inexpensive apparatus which has been designed to eliminate some of these problems is described.
is necessary to use only 12 spaces on the panel to represent all of the elements of the IEE display and its plug connector to the chamber.Our digital equipment operates on a -12-V-to-ground (GND) signal. It is necessary only to vary the resistor values slightly in order to operate on other voltage changes' in different equipment. A schematic of the device appears in Fig. 1. The addition of GND to the input side causes the transistor to operate and apply GND to the 28-V device. When operated, the circuit applies about 4 V to the transistor base, well above the saturation voltage of about 1 V. A lack of input results in the driver's remaining in the off state. The resistors used are~Wand the diodes (in this case 1N2069s) may be those with a peak inverse voltage (PN) in excess of 200 V. The diode across the load functions to suppress inductive loads such as relay coils; it is not needed when operating lamps.The current-carrying capabilities of the driver with the 2N2714 transistor are sufficient to operate most lamps and counters, as well as low-current relays such as the Potter and Brumfield RIO series. Total cost of the unit is about $1.75, and it is easily constructed. Reliability is very good, with no operation-induced failures in many thousands of operations occurring in the last 2 years in any of our units.
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