Background: Female athletes participating in high-risk sports suffer anterior cruciate ligament injury at a 4-to 6-fold greater rate than do male athletes.

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Fatigue-induced modifications in lower-limb control may increase the risk of noncontact ACL injury during landings. Gender dimorphic abduction loading in the presence of fatigue also may explain the increased injury risk in women. Understanding fatigue effects at both the central and peripheral levels will further afford elucidation of the ACL injury mechanism and, hence, more successful prevention strategies.