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To study the optic neuropathy associated with glaucoma, a system for accurate, reliable, and non-invasive monitoring of intraocular pressure (IOP) is required. Of particular interest is the effect of sampling frequency on IOP. To address this issue, ten adult male brown Norway rats (group 1) were acclimatized to a 12-h/12-h light/dark cycle. On 20 days over a 30-day period, rats were anesthetized with short-acting isoflurane (Forane) inhalant anesthesia and IOP for each eye was determined by averaging 15 valid individual readings obtained with a TonoPen 2 tonometer. The last 12 measurement sessions were performed on a daily basis. To determine the minimum tolerable interval between IOP measurement sessions, a second group of 10 animals (group 2) was acclimatized in the same manner as group 1, and IOP was measured every 4 days over a period of 80 days. Next, IOP was measured every 4 days over a period of 28 days, and finally, every 2 days over a period of 19 days. For all group 1 measurements, there was no statistically significant difference between the right and left eye IOP, 14.75 +/- 1.08 (SEM) and 14.90 +/- 1.09 mm Hg, respectively. However, daily measurements produced a steady decrease in IOP and gradual weight loss. For group 2, overall mean right and left eye IOPs were 15.24 +/- 1.28 (SEM) and 15.12 +/- 1.26, respectively and were not significantly different.(ABSTRACT TRUNCATED AT 250 WORDS)

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Purpose: Some EMS systems use resident (RES) physicians to provide on-line medical control (OLMC). Resident inexperience may result in less efficient communication. Objectives: To compare EM faculty physicians (FAC) response to EM senior RES. To determine factors associated with timeefficient OLMC communication. Design: Retrospective cohort for consecutive six months. Setting: A single base-station university hospital staffed by EM FAC (3,300 calls/yr answered by either FAC or RES). Measurements: On-line medical control audio tapes and written records of radio and telephone calls were reviewed. Paramedics (EMT-P) were required to begin OLMC calls with specified information (INFO) (e.g., vital signs, history, treatment). Times were measured using tape deck clock and were reported in mean seconds. CALLTIME = mean time from start to end of physician communication with EMT-P. TOTALTIME = CALLTIME + mean notification time of receiving hospital. Prehospital and Disaster MedicineVol.10, No.4Suppl.https://www.cambridge.org/core/terms. https://doi.