ObjectivesAsian migrant workers in Korea have various ethnicities. The purpose of this study was to evaluate the difference in spirometric interpretation made using the set of third National Health and Nutrition Examination Survey (NHANES III) reference equations and the relevant ethnicity-specific reference sets.MethodsSpirometry was performed on 166 migrant and 498 Korean male workers between March and November 2012. We analyzed the spirometric data of healthy never-smokers. Spirometric patterns were evaluated using the NHANES III reference set and some relevant ethnicity-specific equations (Eom’s equation for Koreans, Ip’s equation for East Asians, Crapo’s equation for Central Asians, Memon’s equation for South Asians, and Gnanou’s equation for Southeast Asian people).ResultsIn all migrant groups except the Central Asian group, the forced expiratory volume in 1 second percentage (FEV1%) and forced vital capacity percentage (FVC%) calculated using each of the ethnicity-specific reference equations considered were significantly higher than those calculated using the NHANES III reference set. This study showed that in the evaluation of the spirometric result of subjects from Southeast Asia or South Asia, the percentage of cases with an abnormal FEV1 or FVC increased when the NHANES III set of equations was used as compared to when the ethnicity-specific equations were used.ConclusionsWe found that the spirometric results of all ethnic groups were higher and the composition of the abnormal spirometric result was lower when the ethnicity-specific reference equations were used instead of the NHANES III reference set.

randomly selected from 9 regions in a population based casecontrol study in Spain (MCC-Spain study) whit demographic details, information on potential confounders and a comprehensive employment history. Each case of leukaemia may have one or more occupations. All occupation were codified by Occupational National Code (CNO 94) and The International Standard Classification of Occupations (ISCO-88) Associations between occupation and leukaemia were analysed using logistic regression adjusting for gender, age, and smoking. Results We analysed the 27,4% of leukaemias.6% never had occupation with risk of leukaemia and 41% were worked at least one occupation with probably exposition to carcinogens for leukaemia. Analysis is ongoing and results will be presented at the conference. Conclusions In summary, our study showed some evidence supporting the role of some kind occupation in the development of leukaemia. However, given the relative low numbers the results have to be interpreted with some caution. On have analyse the exposition on these occupations. Objectives A potential "healthy worker effect" may bias the studied effect of shift work on health. The observed differ-ences in health behaviour and health outcomes might be caused by: (i) primary selection, (ii) influence from the with shift work related environment, and (iii) impact of shift work. We aimed to study these potential sources. Method A cohort of 4754 male trainees who had finished their professional training and started their career in the production between 1995 and 2012 was identified. Among them, 1348 (28%) were involved in rotating shift work and 3406 (72%) in a day working time. Information on lifestyle and blood pressure (BP), body mass index, and measurements of laboratory parameters were retrieved from the data of medical examinations. These were then compared at (i) the beginning, (ii) the end of training, and (iii) 3 years after the job begin, in relation to the working time. 0435 PRIMARY SELECTION AND IMPACT OF SHIFT WORK ON CARDIOVASCULAR RISK FACTORSResults At the beginning of the training, the prevalence of smokers was higher among shift workers (26% vs. 21%). During the training and the first 3 years of job, marginal decline of systolic BP and elevation of triglyceride were observed among the shift workers, after the adjustment for age at begin, duration between the exami-nations, and the measurements at the baseline. No difference was found with respect to other risk factors for cardiovascular diseases. Conclusions Our findings do not support a primary selection in favour of shift workers. A potential impact of shift work on lifestyle and health will be studied prospectively. 10.1136/oemed-2014-102362.373 Objectives Fractional exhaled nitric oxide (FeNO) has been implicated as a pulmonary biomarker in various respiratory disease, including COPD. Measurement of FeNO is a simple, noninvasive tool for assessing airway inflammation. Neverthless, the usefulness of FeNO measurements in COPD patient in clinical practice is unclear. The obje...