Stenting treatments for the management of disease in the heart, arterial and venous systems, biliary ducts, urethras, ureters, oesophageal tract and prostate have made enormous technical advances since their introduction into clinical use. The progression from metallic to polymer based bio-absorbable stents, coupled with the advances in additive manufacturing techniques, present a unique opportunity to completely re-envision the design, manufacture, and supply chain of stents. This paper looks at current stenting trends and proposes a future where the stent supply chain is condensed from ~150 days to ~20 min. The Cardiologist therefore has the opportunity to become a designer, manufacturer and user with patients receiving custom stents specific to their unique pathology that will be generated, delivered and deployed in the Cath-lab. The paper will outline this potentially revolutionary development and consider the technical challenges that will need to be overcome in order to achieve these ambitious goals. A high level overview of the generating eluting stents in situ program-GENESIS-is outlined including some early experimental work.

Recent national government policy in Ireland proposes a radical transformation of the energy sector and a large reduction in CO2 emissions by 2050. Water and energy form the water–energy nexus, with water being an essential component in energy production. However, the connection between the production of energy and water is rarely made. In particular, the end-user processes are generally excluded because they occur outside the water industry. The present study includes two simple approaches for industrial sites to calculate their carbon footprint in the water sector. The assessment of the milk powder manufacturing using both approaches indicates that the combined emission factor of the water supply and treatment is approximately 1.28 kg CO2 m–3 of water. The dairy production among steel, textile, and paper industries appears to be the most carbon-emitting industry. However, the results show that the carbon intensity of the water supply and treatment can be minimized by the integration of renewable energy sources for the onsite heat/steam and electricity generation. The uniqueness of our approaches compared to calculations illustrated by the ecoinvent and other governmental databases is its simplicity and a focus on the main energy consuming manufacturing steps in the entire industrial process. We believe that the management of water and energy resources will be more efficient when “active water citizens” raise environmental awareness through promoting measures regarding data monitoring and collection, observed leaks and damages, dissimilation and exchange of information on sustainable water stewardship to public and various industrial stakeholders.

Previous studies have shown that visible and near-infrared spectra (Vis-NIR) of dry and milled compost can be used for generating partial least squares (PLS) calibrations of phase II compost parameters including ammonia, nitrogen dry matter (NDM), dry matter (DM), pH, conductivity, carbon, microbial population, and potential productivity. The objective of this study was to develop robust calibrations for some of the key parameters from the spectra of fresh phase I and II composts. Samples of substrates from six commercial production yards were obtained during winter and summer months of 2000-2004 to monitor changes in quality and were analyzed for the test factors. Vis-NIR reflectance measurements of fresh samples (740) were made over the range of 400-2500 nm. After mathematical pretreatments, PLS calibrations of the key parameters were developed using the NIR (1100-2500 nm) and visible and NIR (400-2500 nm) regions and subsequently validated using an independent sample set of 123 phase I and II samples obtained during 2004-2005. The phase I and II standard errors of laboratory measurements of ammonia, pH, conductivity, DM, NDM, and ash were lower than the standard error of predictions of the same parameters, respectively, by the best NIR or Vis-NIR models. The degree of precision for some of the calibrations, especially ammonia, NDM, and DM, is suitable for composters to monitor changes in quality parameters during production. The laboratory measurement errors for phase I samples were greater than those of the phase II samples, except for ash, due to a higher degree of heterogeneity in the substrate. The calibrations, especially for pH, conductivity, and ash, need to be improved with new sample sets. A major advantage of NIR spectroscopy is the ability to assess substrate quality for a range of target parameters simultaneously, within a few hours of receiving the samples. The main drawbacks are the expensive instrumentation, expertise, and training necessary for operating the spectrometer and a dedicated chemometrician required for maintaining the equations compared to the reference methods.

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Governments are obligated to safeguard social inclusion for disabled people through user-led personal assistance (PA) under Article 19 of the United Nations Convention on the Rights of Persons with Disabilities (UNCRPD). This scoping review was carried out to map and explore current knowledge on how governments internationally have managed PA schemes in response to the UNCRPD. The review examined 99 documents, and categorised the literature into the following themes; legislation, funding, model of service provision, governance and regulation, and the COVID-19 pandemic response. We include recommendations to co-design legislation and quality improvement policies to ensure that PA schemes are underpinned by a social model of disability mindset. Further research needs to be undertaken to guarantee that policymakers include the voice of PA users in the management of PA schemes. Points of interest• This article looked at 99 documents to find out how governments are managing personal assistance (PA). It found out that governments can often decide to spend less money on a PA scheme rather than protect our rights. • To overcome this problem the documents recommended that legislation for PA schemes must be designed with disabled people. Governments must redirect their money from institutional services to community-based services. Eligibility criteria to control access and the costs of PA should be removed. • This paper suggests that we need to have the voice of the PA user to direct the design and delivery of PA schemes.