El presente artículo tiene como protagonista al concepto de economía creativa, como un sector que se ha abordado muy poco en Colombia. La industria creativa a lo largo de los años ha presentado altos niveles de crecimiento, teniendo en cuenta que no cuenta con un apoyo real por parte del gobierno, sin embargo, cabe destacar que, si se apoyara esta industria naciente en Colombia, se generaría una participación económica significativa, que resultaría en un ingreso de diferente proveniencia para el país y en general para la región, hablando específicamente de producción de materias primas. Se pretende, por tanto, dar a conocer los posibles cambios que tendrían que darse en Colombia, de índole tanto económica como cultural, para comprender que los bienes y servicios culturales no están exclusivamente dirigidos a grupos de personas de alto nivel socioeconómico, noción que favorecería el incentivo directo a este concepto y con ello traería beneficios en diferentes aspectos para el país.

Alzheimer’s disease (AD) is one of the most significant health challenges of our time, affecting a growing number of the elderly population. In recent years, the retina has received increased attention as a candidate for AD biomarkers since it appears to manifest the pathological signatures of the disease. Therefore, its electrical activity may hint at AD-related physiological changes. However, it is unclear how AD affects retinal electrophysiology and what tools are more appropriate to detect these possible changes. In this study, we used entropy tools to estimate the complexity of the dynamics of healthy and diseased retinas at different ages. We recorded microelectroretinogram responses to visual stimuli of different nature from retinas of young and adult, wild-type and 5xFAD—an animal model of AD—mice. To estimate the complexity of signals, we used the multiscale entropy approach, which calculates the entropy at several time scales using a coarse graining procedure. We found that young retinas had more complex responses to different visual stimuli. Further, the responses of young, wild-type retinas to natural-like stimuli exhibited significantly higher complexity than young, 5xFAD retinas. Our findings support a theory of complexity-loss with aging and disease and can have significant implications for early AD diagnosis.

Alzheimer's disease (AD) is one of the most significant health challenges of our time, affecting a growing number of the elderly population. In recent years, the retina has received increased attention as a candidate for AD biomarkers since it appears to manifest the pathological signatures of the disease. Therefore, its electrical activity may hint at AD-related physiological changes. However, it is unclear how AD affects retinal electrophysiology and what tools are more appropriate to detect these possible changes. In this study, we used entropy tools to estimate the complexity of the dynamics of healthy and diseased retinas at different ages. We recorded microelectroretinogram responses to visual stimuli of different nature from retinas of young and adult, wild-type and 5xFAD -an animal model of AD- mice. To estimate the complexity of signals, we used the multiscale entropy approach, which calculates the entropy at several time scales using a coarse graining procedure. We found that young retinas had more complex responses to different visual stimuli. Further, the responses of young, wild-type retinas to natural-like stimuli exhibited significantly higher complexity than young, 5xFAD retinas. Our findings support a theory of complexity-loss with aging and disease and can have significant implications for early AD diagnosis.