Percutaneous ASD closure can be performed safely in children under three years of age with low risk of peri- or postprocedural complications.

Sinus of Valsalva aneurysm (SVA) is an uncommon and mostly congenital cardiac anomaly which predominantly affects Asian males [1]. Congenital SVA is caused by deficiency of normal elastic tissue between aortic media and the annulus fibrosus (abnormal bulbus cordis development) [2]. Ventricular septal defect (VSD), aortic regurgitation (AR), and bicuspid aortic valve (BAV) are frequent concomitant lesions in this SVA type. Acquired SVA can result from previous cardiac surgery, endocarditis, syphilis, atherosclerosis, or chest injury [3]. SVA arises from the right sinus of Valsalva in 80-85% cases, from the non-coronary sinus in 5-15%, and rarely from the left sinus. Despite being generally asymptomatic, SVA can compress adjacent structures, resulting in acute

BackgroundNitric oxide (NO) is involved in eating behavior and inflammatory response. Moreover, there is evidence that NO production is altered in patients with anorexia nervosa (AN).AimTo assess whether the overproduction of NO in AN can affect NO level in exhaled air.Materials and methodsExhaled NO level was studied in 23 girls with AN and compared with that of healthy age- and gender-matched nonatopic controls.ResultsExhaled NO levels were significantly higher in girls with AN compared with healthy age-matched controls.ConclusionsIt appears that anorexia nervosa was accompanied by a higher level of exhaled NO, likely resulting from a systemic increase in NO production because of the severe catabolic state.

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