The synthesis of an easily accessible theophylline-derived copper complex with additional ammonium functionalization has been developed.

The synthesis of a family of N‐heterocyclic carbene–copper complexes bearing a sulfur moiety by using different copper(I) halides through convenient procedures is reported. The solid‐state structures of the presented copper compounds were elucidated based on X‐ray crystallographic analysis. The obtained complexes were examined in various catalytic transformations including 1,3‐dipolar cycloaddition of alkynes and azides, A3 coupling reaction, and β‐hydroboration.

A series of N-heterocyclic copper carbene complexes bearing sulfoxide and sulfone moieties have been prepared. In case of new copper compounds with sulfone ligand, the solid-state structures were determined using X-Ray crystallography. Obtained complexes were investigated as catalysts in such transformations as: 1,3-dipolar cycloaddition of alkynes and azides (CuAAC), A 3 coupling reaction and β-hydroboration and compared with standard copper catalytic systems.

Multicomponent reactions including Biginelli reaction and A 3 coupling are useful synthetic methodologies as they can provide valuable intermediates and building blocks for the synthesis of bioactive natural compounds. The heterocyclic products of these transformations represent antibacterial, antitumor or anti-inflammatory properties. In presented study, copper-mediated protocols for Biginelli reaction and A 3 coupling in sustainable solvents were reported.At first, charged NHC copper complexes were synthesized in few steps and characterized using spectroscopic methods followed by preliminary activity tests in sustainable media. Later in this study, Biginelli reaction and A 3 coupling were proceeded using prepared copper catalytic systems under mild conditions. Desired nitrogen-bearing products were obtained with moderate to very high yields. Some attempts to recycle one of the received NHC copper initiators were also investigated.