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During the 2018-2019 Yellow fever (YF) epidemic in Brazil there was an urgent need for vaccination in egg allergic children METHODS: Children were referred to the Food Allergy Clinic of our institution for supervised YF vaccination. The diagnosis of egg allergy was made by history and sIgE to egg. Children were classified as probably nonallergic or probably allergic to egg. Those with a history of anaphylactic reaction were submitted to a prick-test with the vaccine. If positive, 2 doses of 0,25 ml SC, 30 minutes apart, were applied. All the others received a single dose of 0,5 ml SC of the YF vaccine. Children were observed for 1 hour after vaccination. The primary end-point was the need for epinephrine injection. The secondary end point was the incidence of YF vaccine reaction. RESULTS: We study 435 egg allergic children; 83 (19%) children were classified as probably non-allergic and 352 (81%) as probably allergic to egg, of which 91 (26%) were considered to have severe egg allergy (anaphylaxis to egg). 422 (97%) patients had no YF vaccine reaction; 21(18%) received the fraction schedule. Twenty patients react to YF vaccine; 11 (55%) had mild local reactions and 9 (45% ) had diffuse skin rash. Only 1(0,2%) patient with a negative prick test to the vaccine needed epinephrine. CONCLUSIONS: YF vaccine is safe in egg allergic children. Skin test did not predict the reaction and can probably be abandoned as a screening method in children with anaphylactic reaction to egg.

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