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B u çalışmada, kiral amid türevlerinin farklı sübstitüe aromatik aldehitler ile reaksiyonu yoluyla elde edilen yeni kiral Schiff bazları (3-9) sentezlendi. Yeni sentezlenen bileşiklerin yapıları FTIR, 1 H-NMR, 13 C-NMR ve elementel analiz ile karakterize edildi. Bu Schiff bazlarının tümü Staphylococcus aureus, Bacillus cereus, Escherichia coli, Salmonella thyphimirium, Klebsiella pneumoniae, Enterococcus faecalis, Pseudomonas aeruginosa, Candida albicans'a karşı antibakteriyel ve antifungal etkilerine karşı in vitro olarak test edildi. Tüm bileşikler, Gram pozitif ve Gram negatif bakterilere karşı orta ile iyi derecelerde antibakteriyel aktivite göstermiştir. Test edilen bileşikler arasında bileşik 7 test organizmalarına karşı en güçlü inhibe edici etkiyi göstermiştir.

Asymmetric Henry Reactions Catalyzed by Metal Complexes of Chiral OxazolineBased Ligands. -A series of novel chiral ligands derived from pyrrolecarbonitrile, salicyclic acid, and norephedrine are synthesized and applied as catalysts in the enantioselective Henry reaction. The optimal reaction conditions with respect to Lewis acids, solvents, temperatures, and ligand ratios are determined. -(AYDIN*, A. E.; YUKSEKDANACI, S.; Tetrahedron: Asymmetry 24 (2013) 1, 14-22, http://dx.

Background: Benzimidazole derivatives are an important class of heterocyclic compounds in organic chemistry since are related to a wide range of biological properties including antimicrobial activity. Methods: A series of 1-naphthoyl and benzoyl benzimidazole derivatives were synthesised, identified and screened for their antimicrobial activities against a number of different test organisms such as Escherichia coli, Pseudomonas aureginosa, Klebsiella pneumoniae, Staphylococcus aureus, Enterococcus faecalis, Bacillus cereus, Salmonella typhimurium, Candida albicans (yeast). Results: Benzimidazole derivatives (3a-d) were synthesised by using 4 different aminoacids. L-methionine, Lisoleucine, D-Phenylysine and L-Phenylamine as starting materials in the study. Experimental studies involve the use of benzimidazole derivatives (3a-d) of the selected amino acids to synthesize the benzoyl and naphthoyl derivatives of benzimidazole (4a-d, 5a-c). The structures of the synthesized compounds were confirmed by spectroscopic analyses (FTIR, 1H-NMR, 13C-NMR) and elemental analysis. Conclusion: In this study, only one compound (5a) showed a low MIC value against the eukaryotic microorganism C. albicans. The other six compounds showed higher antimicrobial activities against the prokaryotes C. albicans which is a normal flora in the mouth but is one of the organisms that cause infections leading to the weakening of the human immune system. Compound 5a is a candidate for future alternative antimicrobial drugs against C. albicans infections. In addition, compound 5a has potentials to be used as an inhibitor against P. aureginosa for the treatment of cystic fibrosis.