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In this study, hydroxyapatite-B 2 O 3-La 2 O 3 composites (with ≤ 20 wt.% B 2 O 3 and ≤ 2 wt.% La 2 O 3) were synthesized via wet precipitation method and calcined at 1100°C for 1 h. X-ray diffraction (XRD) analysis revealed the existence of the pure hydroxyapatite (HA) phase with high crystallinity. Characteristic absorption bands of HA were also observed in Fourier transform infrared spectra. Furthermore, scanning electron microscopy images demonstrated that the addition of B 2 O 3 and La 2 O 3 into HA enhanced the particle growth. Mechanical properties of the composites were studied by diametral tensile test and the results showed that incorporation of 10 wt.% B 2 O 3 and 2 wt.% La 2 O 3 led to a 39% increase in tensile strength (compared to the pure HA). In vitro cytocompatibility of HA-B 2 O 3-La 2 O 3 composites was investigated using Osteosarcoma Cell Lines (Saos-2). Incorporation of B 2 O 3 and La 2 O 3 into HA had no toxic effect towards the cells. Based on its tensile strength properties and biological response, composite of 88 wt.% HA, 10 wt.% B 2 O 3 and 2 wt.% La 2 O 3 was suggested as a promising composite for bone tissue engineering applications.

In this research, an electrochemical enzymatic biosensor system for sensitive and selective catechol detection was developed with using boric acid substituted Polyaniline film coated two different electrodes; gold screen‐printed electrode and glassy carbon electrode. Electropolymerization of 3‐aminophenylboronic acid is carried out through various electropolymerization conditions, and the best conditions for biosensors systems are concluded. The developed tyrosinase enzyme‐based biosensor system is used for the determination of catechol. The limit of detections(LOD) of the developed biosensor was 0.25 μM and 1.8 μM with Au SPE and GCE systems, respectively. Additionally, real sample analysis was also performed for controlled catechol added green tea samples.