Introduction: Migraine is one of the most common neurological diseases. The pathophysiology of migraine has not yet been fully elucidated. There is increasing evidence supporting the relationship between oxidative stress and migraine.Method: This is a retrospective, cross-sectional and observational study. The patients were divided into two groups, episodic migraine and chronic migraine. Episodic migraine patients were divided into two subgroups, migraine with aura and migraine without aura. Serum Albumin, total bilirubin, uric acid levels, and migraine clinical findings were obtained from medical records.Results: A total of 181 participants, 88 patients and 93 controls, were included in the study. Serum albumin levels were lower in the patient group than in the control group, they did not reach statistical significance (p=0.082). There was no significant difference between the patient and control groups for total bilirubin levels (p=0.785). Serum uric acid levels in the patient group were found to be significantly lower than in the control group (p<0.001). Measured levels were similar in chronic and episodic migraine groups, and migraine with aura and migraine without aura subgroups. Conclusion:We thought this oxidative stress marker may be associated with the presence of migraine, but this is not significant for migraine subtypes and migraine progression.

Subunit (<i>CHRNA7</i>) gene, and expression of gene-targeting miRNAs (hsa-miR-548e-5p and hsa-miR-3158-5p) in migraineurs (n = 102; with aura, n = 43; without aura, n = 59) and non-migraines (n =120) aged 15-60 years, comparative, case-control study was conducted. Genetic markers were compared with biochemical parameters (BMI, WBC, Urea, GFR, ESR, CRP, HBG). All analyzes were performed by quantitative Real-Time PCR (q-PCR) and fold change was calculated with the 2-^ΔΔCT method. The diagnostic power of the <i>CHRNA7</i> gene, CNV, and miRNAs were analyzed with the receiver operating curve (ROC). <i>CHRNA7</i> gene and hsa-miR-3158-5p are down-regulated in migraineurs and the gene is controlled by this miRNA via CNVs (p<0.05). Both deletion and duplication were detected in patients with migraine for CVN numbers (P = 0.05). The number of CNV deletions was higher than duplications. When CHRNA7-CNV-hsa-miR-3158-5p was modeled together in the ROC analysis, the area under the curve (AUC) was 0.805, and the diagnostic power was "good". In migraineurs, the <i>CHRNA7</i> gene can be controlled by hsa-miR-3158-5p via CNVs to modulate the mechanism of pain. These three genetic markers have diagnostic potential and may be used in antimigraine treatments.

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Amaç: Beyin damar hastalıklarının nadir görülen grubunu oluşturan subaraknoid kanama, mortalite ve morbiditesi yüksek bir hastalıktır. Tedavi ve takip süreci oldukça zordur. Tedavisi multidisipliner yaklaşım gerektirir. Klinik gidişata etki eden parametreler bu hastalıkta hep bir merak konusu olmuştur. Bu yazıda bizim amacımız; Vitamin-D seviyelerinin nörolojik yoğun bakım ünitesinde takip edilen subaraknoid kana-malı hastaların klinik gidişatları üzerine etkisini araştırmak oldu.Materyal ve metod: Ekim 2019-Ekim 2021 tarihleri arasında subaraknoid kanama ile hastanemiz acil servisine başvuran 45 hasta retrospektif olarak taranmıştır.Bu hastaların klinik, labaratuvar ve detaylı anjio raporları hasta dosyalarından elde edilmiştir.Bulgular: Olgular D vitamini 20ng/ml den düşük olanlar ve bu değerden daha yüksek olanlar şeklinde iki gruba ayrıldı. Tüm olguların 23’inde (% 51) Vit-D düzeyleri 20 ng/ml’den düşük saptanmış olup, 22’sinde ise (%49) Vit-D 20ng/ml’den daha yüksek olarak saptandı .Cinsiyet, Vasospazm, Hidrosefali, Epiletik nöbet, yoğun bakım yatış süresi, mekanik ventilasyon süresi, Glaskow koma skalası (GKS) ve exitus oranları bu iki grup arasında karşılaştırıldı birçoğunda istatistiksel olarak anlamlılık saptanmadı.Sonuç: Subaraknoid kanama tanılı hastalarımızda Vit-D eksikliği ve/veya yetersizliği yüksek oranda mev-cuttu. Daha ileri çalışmalara gerek duymakla birlikte Vit-D seviyesi ile subaraknoid kanamalı hastaların prognozu arasında ilişki bulunamamıştır.Anahtar Kelimeler: Subaraknoid kanama, Nörolojik yoğun bakım, Vit-D