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Objective:To find out common causes of high Mean Platelet Volume (MPV) in a pronounced clinical laboratory in mangalore region. Method: The present study has been conducted in a pronounced laboratory in India. A retrospective analysis of the results obtained from the chemical laboratory for cases of variance in MPV value has been carried out on 178 patients attending both IPD and OPD. Result: The study showed that out of 1000 samples,178 patients showed high MPV(>=9).Among these 178 patients males were more as compared to females.28% of the patients had high total WBC count,35.3% had elevated glucose , 12.9% had abnormal lipid profile and 10.1% showed high CKMB values. However 37.6% patients showed no abnormal biochemistry.10 patients showed low MPV(<6.5) which had no significance. Conclusion: A positive correlation has been found in our study between high MPV and abnormalities in haematological and biochemical values.