Solar-driven photocatalytic approach is an attractive, clean, and effective way for decontamination of water. In this work, visible-light-activated TiO 2 nanoflakes (TNFs) and carbondoped TiO 2 nanoflakes (C-TNFs) were synthesized via a facile hydrothermal route using different carbon sources. The assynthesized nanostructures were successfully characterized by powder X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), and transmission electron microscopy (TEM), critically disclosing the anatase nature containing titanium−oxygen having flake/plateletlike morphology with ∼32 nm in size, respectively. The photocatalytic activity was characterized via the degradation of methylene blue (MB) and bacterial inactivation of Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive). The experimental results showed that C-TNFs significantly enhanced photocatalytic activity compared to bare TNFs. It was found that TNF nanocatalysts exhibited superior photocatalytic activity against photodegradation of MB (92.7%) and antibacterial activity (85.6%) under sunlight irradiation. In addition, reduced graphene oxide (RGO)-TNFs have a good recycling ability and are expected to be a promising candidate for photocatalytic applications under sunlight. Consequentially, the higher activity of RGO-TNF nanocatalysts under sunlight irradiation for organic degradation and bacterial inactivation implies that hydrothermal synthesis allows for the preparation of efficient and low-cost carbon-doped photocatalysts for the photodegradation of a wide range of environmental pollutants.