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The role of angiogenesis in cancer pathophysiology cannot be over emphasized as this process aids tumor metastasis via nourishment of nutrient deprived tumors with oxygen and nutrients. Thus, it is pertinent to inhibit this process via the vascular endothelial growth factor receptor 2 (VEGFR-2). Most available anticancer drugs that targets VEGFR-2 exerts promising angiogenic effects but they bare several adverse effects. Hence, the need to uncover novel compounds from plants with less or no toxicity that have high efficacy targeting angiogenesis. In this present work, in silico docking studies was employed to reveal the potentials of bioactive compounds isolated from Raphia taedigera seed oil against VEGFR-2 using axitinib and sorafenib as control. The crystal structure of VEGFR-2 and the compounds were retrieved from protein database and pubchem servers respectively. The compounds were subjected to drug likeness and ADMET screening using Discovery studio 2016 and AdmetSAR server respectively. The docking between the compounds and VEGFR-2 was carried out with the aid of AutoDock Vina and visualization of the molecular interactions were done using PyMOL, LigPlot + and Proteinligand interactions profiler's server. The results showed that 3-Methoxy-2,3-dimethylundec-1-ene scaled through the drug likeness screening. All the compounds show good binding affinities with 4,

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Plant-mediated synthesis of iron oxide nanoparticles has been increasingly drawing attention due to its ecofriendly nature and cost effectiveness. The biosynthesis technique engages plant secondary metabolites such as alkaloids, flavonoids, saponins, phenols, proteins, carbohydrates, glycosides, quinine, steroids, and tannins as reducers and/or stabilizers in the process of forming nanoparticles thereby replacing hazardous chemicals known with physical and chemical methods of nanomaterial synthesis. Biosynthesis method of nano particles has helped to a great extent to overcome some drawbacks, such as high energy and space requirement as well as high cost and hazard associated with various known physical and chemical methods. This work reviewed the biosynthesis of plant mediated iron oxide nanoparticles and their applications in water and wastewater treatment. Much work has been done to explore the effective, safe and cheap method for the dye removal in recent years. However, in future, more methods need to be explored to study and check the removal of dyes from wastewater using plant-mediated iron oxide nanoparticles for safer, cheaper and more efficient performance.