Background Cardiovascular diseases (CVD) represent one of the major sequelae of obesity. On the other hand, the relationship between bone diseases and obesity remains unclear. An increasing number of biological and epidemiological studies suggest the presence of a link between atherosclerosis and osteoporosis, however, the precise molecular pathways underlying this close association remain poorly understood. The present work thus aimed to study Matrix Metalloproteinase 9 (MMP-9), as a proposed link between atherosclerosis and osteoporosis in high fat diet fed rats. Methods and findings 40 rats were randomly divided into 4 groups: control, untreated atherosclerosis group, atherosclerotic rats treated with carvedilol (10mg/kg/d) and atherosclerotic rats treated with alendronate sodium (10mg/kg/d). After 8 weeks, blood samples were collected for estimation of Lipid profile (Total cholesterol, HDL, TGs), inflammatory markers (IL-6, TNF-α, CRP and NO) and Bone turnover markers (BTMs) (Alkaline phosphatase, osteocalcin and pyridinoline). Rats were then euthanized and the aortas and tibias were dissected for histological examination and estimation of MMP-9, N-terminal propeptide of type I procollagen (PINP), C-terminal telopeptide of type I collagen (CTX) and NF-kB expression. Induction of atherosclerosis via high fat diet and chronic stress induced a significant increase in BTMs, inflammatory markers and resulted in a state of dyslipidaemia. MMP-9 has also shown to be significantly increased in the untreated atherosclerosis rats and showed a significant correlation with all measured parameters. Interestingly, Carvedilol and bisphosphonate had almost equal effects restoring the measured parameters back to normal, partially or completely. Conclusion MMP-9 is a pivotal molecule that impact the atherogenic environment of the vessel wall. A strong cross talk exists between MMP-9, cytokine production and macrophage function. It also plays an important regulatory role in osteoclastogenesis. So, it may be a key molecule in charge for coupling CVD and bone diseases in high fat diet fed rats. Therefore, we suggest MMP-9 as a worthy molecule to be targeted pharmacologically in order to control both conditions simultaneously. Further studies are needed to support, to invest and to translate this hypothesis into clinical studies and guidelines.

The research aims to quantify the environmental carrying capacity of both Petrified Forest Protectorate in East Greater Cairo and Hassanah Dome Protectorate in West Greater Cairo, with their sustainable use and preservation. The environmental carrying capacity works as a sustainable method not to exceed the environmental limits of nature reserves or in other words, the number of visitors does not exceed the maximum allowed for visiting the reserve. The methodology used in the International Union for Conservation of Nature (IUCN) has been used. The elements of the methodology are at 3 levels, namely, physical carrying capacity (PCC), which depends on the optimal rate of space used per capita and open period, real carrying capacity (RCC), which depends on environmental and social factors, and effective carrying capacity (ECC), which depends on administrative and operational capacity. The results of the research found that the Petrified Forest Protectorate (East of Greater Cairo) accommodates 186,286 visitor per day, and Hassanah Dome Protectorate (West of Greater Cairo) accommodates 26,612 visitor per day. In addition to assessing the level of the ecological carrying capacity index (ECCI), which measures the extent of support for the population and its activities, and by comparing the total environmental carrying capacity of the two protectorates that reached 212,898 visitors per day with the population of Greater Cairo (Cairo Governorate and Giza Governorate), which reached 17 million (Capmas, 2017), it was found that the environmental carrying capacity of the two protectorates is not sufficient to support recreational activities and environmental tourism for people of Greater Cairo.

Epidemiology and pathogenesis of cardiovascular diseases (CVD) and osteoporosis are strikingly overlapping. This study presents matrix metalloproteinase-9 (MMP-9), as a simple molecular link more consistently associated with the pathophysiology of both osteoporosis and CVD risk factors. 40 adult female rats were randomly distributed into 4 groups [control sham-operated, untreated osteoporosis, carvedilol-treated osteoporosis and alendronate-treated osteoporosis]. After 8 weeks, blood samples were collected to estimate Lipid profile (Total cholesterol, HDL, Triglycerides), inflammatory markers (IL-6, TNF alpha, CRP and NO), and Bone turnover markers (BTM) (Alkaline phosphatase, osteocalcin and pyridinoline). The tibias were dissected to estimate MMP-9 and NF-kB gene expression, OPG, RANKL levels and for histological examination. Induction of osteoporosis resulted in a significant elevation in BTM, inflammatory markers and dyslipidemia. MMP-9 was significantly elevated and positively correlated with BTM, inflammation and dyslipidemia markers. Carvedilol and alendronate exerted a bone preservative role and attenuated dyslipidaemia and inflammation in accordance with their respective effect on MMP-9.

(PM) Particulate matter is frequently cited as a cause of sickness. It is a confusing combination of various chemical Aerosols and solids composed of tiny fluid, dry solid broken pieces, and solid particles pulps utilising liquid composites. For the goal of regulating quality of air, particles are classified by their diameter despite their vast variation in size, shape, and chemical makeup, Those Particles with a size of ten microns or less (.P.M10) can enter the respiratory system and endanger one’s wellness This study’s objective is to describe the particulates (PM10) that emissions from petroleum refining in the Mostorod area produce., to obtain measurements of the concentrations of particles in the residential areas surrounding the oil refinery, to assess the extent of its danger to the health of the population in these areas, and to set requirements to limit the effects of these emissions on population health.

the research aims to evaluate the environmental performance of industrial areas using the Lean and Green portal By reducing waste generated by industries and striking a good balance between operation and environmental performance,. Indicators including labour force (MP), raw materials (Mt), economic cost (Mo), machinery (mc), and the environment have all been researched as ways to accomplish this (mv). The study’s findings revealed that the value of the environment index is just 22%, a very low percentage that denotes neglecting the environmental component in favour of striking a balance among the other factors. The Lean & Green index has a value of 32%. It shows the bad performance compared to the global scale. A number of decisions have been taken in an attempt to improve the performance of industrial regions and achieve balance between different dimensions.