Background: Breast cancer is an epithelial malignancy of the breast duct, which chemotherapy is one of the treatment modalities. Hepatotoxicity is known as one of the side effects of chemotherapy. Multiflora honey provides hepatoprotective effects through its phenolic acid and flavonoid compounds. This study will evaluate the effect of Honey in preventing hepatotoxicity in ductal invasive breast cancer patients receiving FAC chemotherapy. Methods: An experimental study with double-blind, randomized pre and post-test with control group design. About 36 ductal invasive breast cancer patients were divided into 2 groups, the control group who received FAC chemotherapy and the treatment group who received chemotherapy and 90 ml/day honey consumption for 14 days. The patient's Aspartate Transaminase (AST), Alanine Transaminase (ALT), Alkaline Phosphatase (ALP), and Gamma-Glutamyl Transferase (GGT) enzyme levels before and after 14 days of the study were assessed. Data were analyzed using SPSS version 15 for Windows by Mann-Whitney test and Wilcoxon tests.