Paired-end sequencing is a common approach for identifying structural variation (SV) in genomes. Discrepancies between the observed and expected alignments indicate potential SVs. Most SV detection algorithms use only one of the possible signals and ignore reads with multiple alignments. This results in reduced sensitivity to detect SVs, especially in repetitive regions. We introduce GASVPro, an algorithm combining both paired read and read depth signals into a probabilistic model that can analyze multiple alignments of reads. GASVPro outperforms existing methods with a 50 to 90% improvement in specificity on deletions and a 50% improvement on inversions. GASVPro is available at http://compbio.cs.brown.edu/software.

Money laundering is the crucial mechanism utilized by criminals to inject proceeds of crime into the financial system. The primary responsibility of the detection of suspicious activity related to money laundering is with the financial institutions. Most of the current systems in these institutions are rule-based and ineffective (over 90 % false positives). The available data science-based anti-money laundering (AML) models to replace the existing rule-based systems work on customer relationship management (CRM) features and time characteristics of transaction behaviour. Due to thousands of possible account features, customer features, and their combinations, it is challenging to perform feature engineering to achieve reasonable accuracy. Aiming to improve the detection performance of suspicious transaction monitoring systems for AML systems, in this article, we introduce a novel feature set based on time-frequency analysis, that uses 2-D representations of financial transactions. Random forest is utilized as a machine learning method, and simulated annealing is adopted for hyperparameter tuning. The designed algorithm is tested on real banking data, proving the results' efficacy in practically relevant environments. It is shown that the timefrequency characteristics are discriminatory features for suspicious and non-suspicious entities. Therefore, these features substantially improve the area under curve results (over 1%) of the existing data science-based transaction monitoring systems. Using time-frequency features alone, a false positive rate of 14.9% has been achieved, with an F-score of 59.05%. When combined with transaction and CRM features, the false positive rate is 11.85%, and the F-Score is improved to 74.06%. INDEX TERMSAnomaly detection, anti-money laundering, compliance, random forest algorithm, timefrequency analysis, transaction monitoring.

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