No abstract

Selective autophagy is a catabolic route that turns over specific cellular material for degradation by lysosomes, and whose role in the regulation of innate immunity is largely unexplored. Here, we show that the apical kinase of the Drosophila immune deficiency (IMD) pathway Tak1, as well as its co-activator Tab2, are both selective autophagy substrates that interact with the autophagy protein Atg8a. We also present a role for the Atg8a-interacting protein Sh3px1 in the downregulation of the IMD pathway, by facilitating targeting of the Tak1/Tab2 complex to the autophagy platform through its interaction with Tab2. Our findings show the Tak1/Tab2/Sh3px1 interactions with Atg8a mediate the removal of the Tak1/Tab2 signaling complex by selective autophagy. This in turn prevents constitutive activation of the IMD pathway in Drosophila. This study provides mechanistic insight on the regulation of innate immune responses by selective autophagy.

No abstract

This article compares cultural governance in Taiwan and China through their respective place-making processes. It investigates how cultural polices objectify tradition and popularize cultural landscape in local places for economic development and identity politics. Contrary to what would be commonly expected, the Chinese government adopted a minimalist approach while the Taiwanese government was much more hands-on. The sociopolitical histories of the two governments and their objectives are examined to understand this difference. In addition, the reactions of the locals to cultural policies in the two places are also contrasted. Finally, the different effects of cultural governance in China and Taiwan are examined. In particular, it was found that communal relations have deteriorated in China but strengthened in Taiwan as a result.