Background. Phenylketonuria (PKU) and biotinidase deficiency (BD) are autosomal recessive diseases. If they are not identified and treated early, severe intellectual disability and developmental delay occur. This study was conducted to calculate the ten-year incidence of PKU and BD in the Diyarbakır province of Turkey. Methods. This cross-sectional study included patients born between 2011-2020 and diagnosed with PKU and BD. Patients with a clear diagnosis had their records evaluated retrospectively. Results. Between 2011 and 2020, blood was taken from 417,525 newborns` heels in Diyarbakir province. As a result of further diagnostic testing, 53 PKU (Incidence: 1:7878) and 177 BD (Incidence: 1:2359) were detected. Of the patients with BD, 56% had profound BD and 44% had partial BD. The records of a total of 269 patients (PKU: 25; BD: 123; Hyperphenylalaninemia: 121) were examined. Parents of 65% (n=15) of the patients diagnosed with PKU and 46.6% (n=55) of the patients diagnosed with BD were consanguineous. Conclusions. The incidence of both PKU and BD was found to be high in our region. The high number of consanguineous marriages was regarded as the most important explanation for the high frequency of these illnesses.

Background/Aim: COVID-19 disease occurs in close contact due to its highly contagious nature. Healthcare workers (HCWs) are in the frontline of struggling with the COVID-19 pandemic. The thoughts, behaviors, attitudes, and psychosocial statuses of healthcare professionals working in this problematic condition have not yet been fully investigated in Turkey. We aimed to evaluate the mental health and psychosocial status, thoughts about the measures taken by the government, attitudes, and behaviors of healthcare workers facing the COVID-19 pandemic, and whether there is a difference between physician and non-physician HCWs. Methods: In this cross-sectional survey, a 56-question multiple-choice test created based on similar surveys and scales was performed by a one-to-one interview with the HCWs in three registered hospitals fighting the COVID-19 pandemic from 20 May to 10 June 2020. Mental health variables were assessed via the Patient Health Questionnaire-4 (PHQ-4) and the Turkish Beck Depression Scale to specify psychological manifestations. A scoring system was applied using a four-point Likert scale, from no points (“strongly disagree”) to three points (“strongly agree”) to determine the levels of anxiety and depression. Participants were divided into two groups as physician and non-physician HCWs for subgroup analysis. Results: A total of 300 HCWs (45 physicians, 255 non-physician health care workers) enrolled in the survey. Only 0.8% of HCWs received psychological support from a therapist or psychiatrist. The most common concern during the COVID-19 pandemic was about “the elderly and other risky population being infected” (37.9%). Compared with non-physician HCWs, physicians felt more concerned about the spread of COVID-19 (80% vs 47.1%, P=0.006 χ2=12.591) and they agreed at a higher rate that the number of tests performed was sufficient (53.3% vs. 41.2%, P=0.030, OR: 0.29-0.35, χ2=7.047). For all HCWs, the "feeling of being infected with COVID-19” item had the highest mean total score (2.60 (0.97). The mean score of the “feeling nervous/anxious/on edge” item was 2.53 (0.52) for physicians and 2.26 (0.86) for non-physician HCWs. Non- physicians HCWs had a higher mean score for “Feeling of increased body pain and agony” item than physicians 0.27(0.80) vs 0.76 (1.23), mean dif=-0.50, 95% confidence interval=-1.002 to 0.006, P<0.05). Conclusions: The results of this study showed that healthcare professionals were most anxious about “being infected with COVID-19”. Both physician and non-physician HCWs were feeling nervous/anxious/on edge according to anxiety scores.

Background/Aim: COVID-19 disease occurs in close contact due to its highly contagious nature. Healthcare workers (HCWs) are in the frontline of struggling with the COVID-19 pandemic. The thoughts, behaviors, attitudes, and psychosocial statuses of healthcare professionals working in this problematic condition have not yet been fully investigated in Turkey. We aimed to evaluate the mental health and psychosocial status, thoughts about the measures taken by the government, attitudes, and behaviors of healthcare workers facing the COVID-19 pandemic, and whether there is a difference between physician and non-physician HCWs. Methods: In this cross-sectional survey, a 56-question multiple-choice test created based on similar surveys and scales was performed by a one-to-one interview with the HCWs in three registered hospitals fighting the COVID-19 pandemic from 20 May to 10 June 2020. Mental health variables were assessed via the Patient Health Questionnaire-4 (PHQ-4) and the Turkish Beck Depression Scale to specify psychological manifestations. A scoring system was applied using a four-point Likert scale, from no points ("strongly disagree") to three points ("strongly agree") to determine the levels of anxiety and depression. Participants were divided into two groups as physician and non-physician HCWs for subgroup analysis. Results: A total of 300 HCWs (45 physicians, 255 non-physician health care workers) enrolled in the survey. Only 0.8% of HCWs received psychological support from a therapist or psychiatrist. The most common concern during the COVID-19 pandemic was about "the elderly and other risky population being infected" (37.9%). Compared with non-physician HCWs, physicians felt more concerned about the spread of COVID-19 (80% vs 47.1%, P=0.006 χ2=12.591) and they agreed at a higher rate that the number of tests performed was sufficient (53.3% vs. 41.2%, P=0.030, OR: 0.29-0.35, χ2=7.047). For all HCWs, the "feeling of being infected with COVID-19" item had the highest mean total score (2.60 (0.97). The mean score of the "feeling nervous/anxious/on edge" item was 2.53 (0.52) for physicians and 2.26 (0.86) for non-physician HCWs. Non-physicians HCWs had a higher mean score for "Feeling of increased body pain and agony" item than physicians 0.27(0.80) vs 0.76 (1.23), mean dif=-0.50, 95% confidence interval=-1.002 to 0.006, P<0.05). Conclusions:The results of this study showed that healthcare professionals were most anxious about "being infected with COVID-19". Both physician and non-physician HCWs were feeling nervous/anxious/on edge according to anxiety scores.

Objective: To evaluate the mental Health and Psychosocial status, thoughts about the measures taken by the government, attitudes, and behaviors of HCWs facing the Covid-19 pandemic.Methods: A 56-question multiple-choice survey was performed by a one-to-one interview with the HCWs in 3 registered hospitals fighting the Covid-19 pandemic from 20 May to 10 June 2020. Mental health variables were assessed via the Patient Health Questionnaire-4 (PHQ-4) and the Turkish Beck Depression Scale to specify psychological manifestations. A scoring system was applied using a four-point Likert scale, from no points (“strongly disagree”) to three points (“strongly agree”) to determine the levels of anxiety and depression.Results: A total of 300 HCWs (45 physicians, 255 non-physician health care workers) enrolled in the survey. Only 0.8% of HCWs took psychological support from a therapist or psychiatrist. The most common concern about Covid-19 pandemic was that “the elderly and other risky population was being infected” (37.9%). 89.2% HCWs who felt the concern was that they had changed their thoughts with the information they got from television (P= 0.005, χ2= 20.271). Compared with non-physician HCWs, the physicians about the spreading of the Covid- 19 felt more the concern (%80 vs %47.1, p= 0.006 χ2=12.591) and physicians higher rate agreed that the number of tests being performed was sufficient enough. (53.3% vs. 41.2%, p=0.030, OR:0.29-0.35, χ2: 7.047), For all HCWs, the "feeling of being infected with Covid-19” item had the highest mean total score (2.60 ± 0.97). The mean score of “feeling nervous/anxious/on edge” item was 2.53±0.52 for physicians, and 2.26±0.86 for non-physician HCWs. Non-physicians HCWs had a higher mean score for “Feeling of increased body pain and agony” item than physicians (0.27±0.80 vs 0.76±1.23; mean dif= -0.50, 95% confidence interval=-1.002 to 0.006, p<0.05).Conclusions:The results of this survey study showed that the highest anxiety score for all healthcare professionals was the “feeling of being infected with covid-19”. Both physicians and non-physicians HCWs were feeling nervous/anxious/on edge largely according to anxiety scores.