Çalışmamızda çekal ligasyon ve perforasyon yöntemi kullanılarak akut akciğer hasarı gelişimini sağladığımız sıçanlarda Silimarin'in anti-inflamatuvar ve antioksidan özelliklerini değerlendirmeyi amaçladık. Gereç ve Yöntem: Toplam 46 sıçanın kullanıldığı çalışmamızda sham (n=14), kontrol (n=16) ve silimarin (n=16) grupları ve her bir grubun erken ve geç alt grupları vardı. Silimarin grubundaki sıçanlara silimarin, kontrol ve sham grubuna ise salin verildi. Kontrol ve silimarin grubundaki sıçanlarda çekal ligasyon ve perforasyon yöntemi ile sepsise bağlı akciğer hasarı gelişimi sağlandı. Erken gruptaki sıçanlar 12. saatte sonlandırılırken geç gruptakiler takibe alındı. Sıçanların serum ve bronkoalveolar lavaj sıvısı (BAL) tümör nekroz faktör alfa (TNF-α), interlökin (İL)-1, İL-6 seviyeleri, akciğer dokusunda malondialdehit (MDA) ve glutatyon sülfidril (GSH) seviyeleri, akciğer dokusunun histopatolojik incelemesi ve yaş/kuru ağırlık oranına bakıldı. Bulgular: Çalışmanın sonucunda 72. saatte silimarin grubunda sağkalım oranı %62,5, kontrol grubunda %12,5 bulundu (p=0,0506). Silimarin grubunda kontrol grubuna göre yaş/ kuru ağırlık oranı (p=0,019), serum ve BAL, TNF-α, İL-1, İL-6 seviyeleri (her biri için p<0,05) ve histopatolojik skorlama anlamlı olarak daha düşük bulundu (p=0,001). Doku MDA seviyesinin kontrol grubundan daha düşük (p=0,011) ve GSH seviyesinin daha yüksek (p=0,001) olduğu tespit edildi. Sonuç: Silimarin sepsise bağlı akut akciğer hasarı gelişimini önlemede yararlı olmuştur. Bu etkinin anti-inflamatuvar ve antioksidan özellikleri sayesinde olduğunu düşünmekteyiz. Anahtar Kelimeler: Silimarin, akut akciğer hasarı, antioksidan, anti-inflamatuvar SUMMARY Objective: In this study, it was aimed to evaluate the anti-inflammatory and antioxidative effects of Silymarin in rats in whom artificial acute pulmonary damage was provided with caecal ligation-perforation method. Material and Method: Forty-six rats were randomized to sham (n=14), control (n=16), silymarin (n=16) groups. Each group had early and late subgroups. Silimarin was administered in the silimarin group and saline was administerd in control and sham groups. Artificial acute pulmonary damage associated with sepsis was provided with caecal ligationperforation method in control and silimarin groups. Rats in the early subgroup Were terminated at the end of the 12 th hour and threats in the late group were followed-up. Serum and bronchoalveolar lavage fluid (BAL) tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6; lung tissue malondialdehyde (MDA) and glutathione (GSH) levels; lung histopathologic examination; and lung wet-to-dry (w/d) weight ratio measurements were used to compare and evaluate the severity of lung injury between the groups. Results: Mortality rates for silymarin and control groups were 62.5% and 12.5%, respectively (log-rank p=0.0506). Compared with the silymarin group, the control group exhibited significantly more severe lung injury, as indicated by higher mean values for serum and BAL TNF-alpha, IL-1beta and IL-6...

Aim: Through this study, we aim to investigate whether biomarkers like the neutrophil-lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and systemic immune-inflammatory index (SII) might predict the postoperative first 24 hours analgesic requirement and pain scores of patients undergoing laparoscopic cholecystectomy.Material & Method: After receiving the local ethical board approval, records of 67 patients, aged between 18 and 75 years, with ASA classifications I-III who underwent elective laparoscopic cholecystectomy were retrospectively evaluated to record postoperative analgesic requirements and numerical pain scale (NRS) scores. NLR, PLR, and SII scores were calculated from preoperative hemograms and compared with analgesic requirements and NRS scores.Results: The data of 67 patients were evaluated. There was no correlation between postoperative tramadol use and NRS scores, PLR, or SII values (p>0.05). NRS scores and the cumulative 24-hour postoperative tramadol use were correlated (p=0.0001), as it was observed that patients with high NRS scores used higher amounts of tramadol. Additionally, a poor statistically significant correlation was found between PDW (Platelet distribution width) value and tramadol dose (AUC = 0.611). Conclusion:No significant association between NLR, PLR, SII, pain scores, and tramadol use was detected.

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