Background: Medication errors are a reality in all settings where medicines are prescribed, dispensed and used. High Alert Medications (HAM) are those that bear a heightened risk of causing significant harm to the patient, if used erroneously. Though mishaps with HAM may not be more common than with other drugs, the consequences of error with them can be especially serious. We conducted a survey on knowledge, attitude and practice, among residents working in a teaching hospital, to assess the ground situation regarding HAM awareness and handling. Methods: We approached 492 residents among the approximately 600 residents currently working through purposive sampling. Residents in all disciplines (clinical, paraclinical and preclinical) were targeted. A structured questionnaire with 54 questions, pilot-tested on 20 volunteer residents, was used for data collection. The questionnaire was administered to residents through face-to-face interview, by two raters, while they were on duty, but not during rush hours. Results: Of the total 261 responses received, 32.33% respondents correctly defined or explained the meaning of the term ‘medication error’. Knowledge regarding difference between medication error and adverse event did not get reflected in 68.38% of the participants, and only 16.86% were able to name relevant group of medicines as HAM. Regarding attitude in dealing with HAM, majority believed that taking the history of drug allergy and reconciling all prescription and over the counter (OTC) drugs already being used before prescribing or using a medicine, is important. In practice, most respondents followed protocols, but not routinely. Several potential errors in practice were identified. Conclusion: The current situation requires corrective action. There is an urgent need for improving awareness regarding HAM for the sake of patient safety. The pharmacology department can take the lead in designing awareness campaign with support from the hospital administration.