1. Arsenic (As(III)) toxicity has received increasing attention as human exposure to arsenic is associated with pulmonary, hepatic and renal toxicities. Therefore, in the present study, we investigated the effect of acute As(III) treatment on pulmonary, hepatic and renal cytochrome (CYP) P450-mediated arachidonic acid metabolism. 2. Our results demonstrated that acute As(III) treatment (12.5 mg/kg) altered CYP epoxygenases, CYP ω-hydroxylases and EPHX2 mRNA levels that were isozyme and tissue specific. 3. Furthermore, As(III) increased the formation of epoxyeicosatrienoic acids (EETs) in the kidney without affecting their levels in the lung or liver. In addition, acute As(III) treatment increased dihydroxyeicosatrienoic acid (DHETs) formation in the lung, while it did not affect liver DHETs formation and decreased kidney DHETs formation. 4. As(III) also increased total epoxygenases activity in the lung while it decreased its levels in the kidney and had no effect on the liver. Furthermore, As(III) increased 20-hydroxyeicosatetraenoic acid formation in the liver while it decreased its formation in the kidney. 5. Lastly, As(III) increased soluble epoxide hydrolase activity in the lung, while it decreased its levels in the kidney and had no effect on the liver. In conclusion, this is the first demonstration that As(III) alters arachidonic acid metabolism in a tissue specific manner.

Various assistive devices like exoskeletons have been developed to aid the growing number of disabled people. Recent studies have started to explore using soft rather than rigid components to create lightweight and unobtrusive systems that can be more easily adopted by the general population. However, there is a tradeoff between compliance and power in these systems. We investigated the physiological benefits of using an inconspicuous, soft and passive assistive device which would avoid bulkiness, heaviness and user discomfort. We chose to assist the sit-to-stand (STS) maneuver because it is a common activity of daily living (ADL). STS is also recognized as one of the most challenging ADLs due to the high knee torque required, and the primary limiting factor is known to be knee extensor strength. Thus, the objective of this research was to develop and evaluate an unobtrusive knee assist wear called X-tights that could aid knee extension during STS using only soft and passive components. This was accomplished by routing elastic bands across the lower extremity. Thirty-one healthy participants performed STS tests with and without the X-tights, while metabolic cost and muscle activity were recorded. Metabolic power significantly decreased, by 3.2 ± 1.5% (P = 0.04), when utilizing the X-tights during the STS, while there was no statistically significant differences in muscle activity. The present work introduces a new soft and passive assist wear that can be worn inconspicuously under normal clothing, and we demonstrate promising results for the future development and integration of soft assistive technology for daily life.

Objectives: This study was to discuss the research trend of dementia treatment using cannabis for the purpose of providing the basis of cannabis use for medical purposes in the future.Methods: This study searched publications, which were registered to databases or published by Aug 22, 2019, and targeted the full-text or abstracts of these publications. We selected the final nine studies met all selection criteria.Results: These results implied that the CBD components of cannabis might be useful to treat and prevent AD because CBD components could suppress the main causal factors of AD. Moreover, it was suggested that using CBD and THC together could be more useful than using CBD or THC alone. Conclusion:We hope that there will be a solid foundation to use cannabis for medical use by continuously evaluating the possibility of using cannabis for clinical purposes as a dementia treatment substance and cannabis can be used as a positive tool. 1.IntroductionThe interest in senile disease is rising gradually because aging society has become a more common phenomenon. Types of dementia include AD, vascular dementia, paralytic dementia, Lewy body dementia, carbon monoxide induced dementia, and trauma dementia [1,2]. The onset of AD has continued to increase since 1995, while the prevalence of vascular dementia is gradually decreasing. Therefore, AD draws attention from researchers [3]. AD is a disease that is caused by the gradual degeneration and death of cerebral cortical cells. The main symptoms are memory loss, cognitive decline and behavioral disorders [4]. Histopathologically, overall encephalatrophy, senile plaques, and neurofibromatosis (NFT) are the common characteristics of AD [5]. Acquired cognitive deficits caused by AD have a significant impact on the social life and activity of the patients [6]. Moreover, active treatment of memory disorders greatly affects the prognosis of AD patients [3]. Consequently, many researchers acknowledge the need for a therapeutic drug to restore the memory and cognitive damages of AD patients, and various studies have been conducted. There are three Cannabis species: C. sativa, C. indica,

The purpose of this study was to compare body composition, anaerobic capacity, and hematologic parameters after intermittent complex training in high school soccer players. The subjects were 15 high school soccer players (age, 15.60±0.82 years; height, 171.93±5.65 cm; body weight, 61.32±7.43 kg). Clinical variables included body composition, anaerobic capacity, and hematologic parameters. Data were analyzed to compare between trials by paired sample t-test. As a result, there were significant differences in body weight (p＜0.05) and muscle mass (p＜0.05) of body composition after 4 weeks. There were significant differences in shuttle run (p＜0.001) and heart rate in rest (p＜0.05) of aerobic performance after 4 weeks. There were significant differences in lactate dehydrogenase (p＜0.001), creatine kinase (p＜0.001), all out lactic acid (p＜0.01), and red blood cell (p＜0.001) of hematologic parameters after 4 weeks. In summary, intermittent complex training for 4 weeks showed strong influences on body composition and hematologic parameters variables in high school soccer players. Keywords

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