PurposeTo investigate changes in the thickness of the fovea and peripapillary RNFL associated with myopia.MethodsSixty-five Korean adults (for a total of 130 eyes) between 23 and 26 years of age were selected as test subjects. Thirty-eight test subjects were male, and 27 were female. Subjects with glaucoma or other identified ocular diseases were excluded. Patients whose manifest refraction measurement values ranged between 0 to -2D were classified as group one (emmetropia and low myopia), those between -2 to -5D were classified as group two (moderate myopia), and those more than -5D were classified as group three (high myopia). Using the OCT, the thickness of the fovea and peripapillary RNFL were measured for every subject.ResultsThe thicknesses of the fovea for each of three groups were 142.16±8.99 µm in group one (45 eyes), 153.58±17.63 µm in group two (43 eyes) and 158.86±11.93 µm in group three (28 eyes). The data showed significant differences in fovea thickness between the groups. The average thicknesses of the peripapillary RNFL for each of three groups were 113.29±10.80 µm in group one, 103.85±14.48 µm in group two and 100.74±9.15 µm in group three. A statistically significant difference was found between group one and the other groups (p<0.05).ConclusionsAs the level of myopia increased, the thickness of the fovea also increased, while the thickness of the peripapillary RNFL decreased. Therefore, when interpreting OCT results in the clinic, careful consideration should be given to various changes associated with myopia.

We report treatment of a 24-year-old man with membranous glomerulonephritis (MGN) who developed a solitary choroidal tuberculoma in association with miliary tuberculosis during steroid therapy. In June 1995, the patient had developed nephrotic syndrome. He had refused renal biopsy at that time. So we treated him with corticosteroids having assumed a diagnosis of minimal change nephrotic syndrome. After initial corticosteroids and diuretics therapy for 5 months, his generalized edema resolved but proteinuria (3 positive) continued, suggesting the presence of other forms of glomerulonephritis. Renal biopsy performed in January 1996. The patient was diagnosed as having MGN. The patient was closely observed over a period of 34 months and remained stable without steroid therapy. However at 34 months, generalized edema was again noted and steroid therapy at high dosage was initiated. After 5 months of steroid therapy, he developed miliary tuberculosis and a solitary choroidal mass. An antituberculosis chemotherapeutic regimen was started and after a further 5 months, all clinical symptoms and signs of the pulmonary lesion were resolved and a measurable shrinking of the choroidal mass was recorded.

No abstract