, 88 pages Context: The Web has had a significant impact on all aspects of our society. As our society relies more and more on the Web, the dependability of web applications has become increasingly important. To make these applications more dependable, for the past decade researchers have proposed various techniques for testing webbased software applications. Our literature search for related studies retrieved 193 papers in the area of web application testing, which have appeared between 2000 and 2013. Objective: As this research area matures and the number of related papers increases, it is important to systematically identify, analyze, and classify the v publications and provide an overview of the trends and empirical evidence in this specialized field. Method: We systematically review the body of knowledge related to web application testing through a systematic literature review (SLR) study. This SLR is a follow-up and complimentary study to a recent systematic mapping (SM) study that has been conducted in this area. As part of this study, we pose three sets of research questions, define selection and exclusion criteria, and synthesize the empirical evidence in this area. Results: Our pool of studies includes a set of 95 papers (from the 193 retrieved papers) published in the area of web application testing between 2000 and 2013. The data extracted during our SLR study is available through a publicly-accessible online repository. Among our results are the followings: (1) the list of test tools in this area and their capabilities, (2) the types of test models and fault models proposed in this domain, (3) the way the empirical studies in this area have been designed and reported, (4) level of rigor and industrial relevance in empirical studies and (5) the state of empirical evidence. Conclusion: We discuss the emerging trends in web application testing, and discuss the implications for researchers and practitioners in this area. The results of our SLR can help researchers to obtain an overview of existing web application testing approaches, fault models, tools, metrics and empirical evidence, and subsequently identify areas in the field that require more attention from the research community.

Warm hepatic ischemia-reperfusion injury is a significant medical problem in many clinical conditions such as liver transplantation, hepatic surgery for tumor excision, trauma and hepatic failure after hemorrhagic shock. Partial or, mostly, total interruption of hepatic blood flow is often necessary when liver surgery is performed. This interruption of blood flow is termed "warm ischemia" and upon revascularization, when molecular oxygen is reintroduced, the organ undergoes a process called "reperfusion injury" that causes deterioration of organ function. Ischemia reperfusion results in cellular damage and tissue injury associated with a complex series of events. Pathophysiological mechanisms leading to tissue injury following ischemia-reperfusion will be discussed and therapies targeted to reduce liver damage will be summarized within this review.

Objectives The aim of this study was to evaluate the relationship between systemic oxidative balance, and the severity of the disease in patients with COVID 19. Methods Sixty-four patients were divided into three groups according to the severity of the disease: mild (n=28), moderate (n=11) and severe (n=25). Twenty-four healthy controls included to the study. Proinflammatory cytokines (IL-6 and TNF-α), D-dimer, fibrinogen, total oxidative status (TOS), total antioxidant status (TAS) were measured and oxidative stress index (OSI) was calculated. Results The mean age of severe group was significantly higher than the other groups (p=0.001). TAS levels were significantly decreased in all patient groups compared to controls, while serum TOS and OSI levels were significantly different in all three stages of the disease. Serum IL-6 and TNF- α levels were significantly elevated in severe group compared to other groups. TOS and OSI levels were also significantly correlated with IL-6, CRP, ferritin, fibrinogen, LDH and D-dimer. Conclusions TOS and OSI levels are an indicator of systemic oxidative balance in COVID-19 and related to the disease severity. They can be an important marker for evaluating the disease severity and used in the management of patients with COVID-19.

Glaucoma is the leading cause of irreversible blindness in industrialized countries and comprises a group of diseases characterized by progressive optic nerve degeneration. Glaucoma is commonly associated with elevated intraocular pressure due to impaired outflow of aqueous humor resulting from abnormalities within the drainage system of the anterior chamber angle (open-angle glaucoma) or impaired access of aqueous humor to the drainage system (angle-closure glaucoma). Oxidative injury and altered antioxidant defense mechanisms in glaucoma appear to play a role in the pathophysiology of glaucomatous neurodegeneration that is characterized by death of retinal ganglion cells. Oxidative protein modifications occurring in glaucoma serve as immunostimulatory signals and alter neurosupportive and immunoregulatory functions of glial cells. Initiation of the apoptotic cascade observed in glaucomatous retinopathy can involve oxidant mechanisms and different agents have been shown to be neuroprotective. This review focuses on the molecular mechanisms of oxidant injury and summarizes studies that have investigated novel free radical scavengers in the treatment of glaucomatous neurodegeneration.