La enfermedad renal crónica (ERC) es una enfermedad multifactorial de carácter progresivo e irreversible. En esta enfermedad la función renal se encuentra deteriorada; en estadios avanzados requiere, por lo general, terapias de reemplazo renal (TRR). El elevado costo del tratamiento sustitutivo de la ERC representará un importante reto para los sistemas de salud. En nuestro país, históricamente ha predominado el uso de diálisis peritoneal, aunque recientemente se ha dado impulso a la hemodiálisis. Por un lado, en México, la hemodiálisis sigue siendo poco accesible para la mayoría de los pacientes. Por otro lado, el trasplante renal (TR) es la única modalidad de TRR que realmente previene el desarrollo ABSTRACT Introduction: Chronic Kidney Disease (CKD) is a multifactorial disease of a progressive and irreversible nature, in which renal function is impaired that in end stages requires renal replacement therapies (RRT). The high cost of CKD replacement therapy will represent a major challenge for health systems. Mexico is a country in which the use of peritoneal dialysis has historically predominated, although hemodialysis has recently been encouraged. On the other hand, in Mexico, hemodialysis remains poorly accessible for most patients. Kidney transplantation (KT) is the only modality of RRT that really prevents the development of uremia, but, unfortunately, not all patients with CKD are candidates for KT. For this

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Background:The impact of donor quality on post-kidney transplant survival may vary by candidate condition. Objective: Analyzing the combined use of the Kidney Donor Profile Index (KDPI) and the estimated post-transplant survival (EPTS) scale and their correlation with the estimated glomerular filtration rate (eGFR) decline in deceased-donor kidney recipients (DDKR).Methods: This was a retrospective, observational cohort study. We included DDKRs between 2015 and 2017 at a national third-level hospital. Results: We analyzed 68 DDKR. The mean age at transplant was 41 ± 14 years, 47 (69%) had sensitization events, 18 (26%) had delayed graft function, and 16 (23%) acute rejection. The graft survival at 12 and 36 months was 98.1% (95% CI 94-100) and 83.7% (95% CI 65-100), respectively. The Pearson correlation coefficient between the percentage reduction in the annual eGFR and the sum of EPTS and KDPI scales was r = 0.61, p < 0.001. The correlation coefficient between the percentage reduction in the annual eGFR and the EPTS and KDPI scales separately was r = 0.55, p < 0.001, and r = 0.53, p < 0.001, respectively. Conclusions: The sum of EPTS and KDPI scales can provide a better donor-recipient relationship and has a moderately positive correlation with the decrease in eGFR in DDKR.

Nivel de la tasa de filtrado glomerular para iniciar el protocolo de trasplante, evaluación de urolitiasis, proteinuria y hematuria en el receptor de trasplante renal Glomerular filtration rate level to start the transplant protocol, evaluation of urolithiasis, proteinuria and hematuria in the kidney transplant recipient