Former and active Cushing's disease patients suffer from a wide range of neuropsychiatric symptoms. Those symptoms might dominate the clinical picture and lead to a serious impairment in quality of life as well as extend periods of suffering and might persist even years after being found healthy. Therefore it is important to evaluate quality of life as an independent factor in every patient being affected by Cushing's disease and to include a holistic view in their therapy. Concomitant therapeutic measures should be accessible at any time for Cushing's disease patients as the normalization of pathologically increased laboratory values doesn't obligatory lead to an improvement of the patients subjectively felt well-being.

The Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease in the adulthood, and it is characterized by rapid and progressive compromise of the upper and lower motor neurons. The majority of the cases of ALS are classified as sporadic and, until now, a specific cause for these cases still is unknown. To present the different hypotheses on the etiology of ALS. It was carried out a search in the databases: Bireme, Scielo and Pubmed, in the period of 1987 to 2011, using the following keywords: Amyotrophic lateral sclerosis, motor neuron disease, etiology, causes and epidemiology and its similar in Portuguese and Spanish. It did not have consensus as regards the etiology of ALS. Researches demonstrates evidences as regards intoxication by heavy metals, environmental and occupational causes, genetic mutations (superoxide dismutase 1), certain viral infections and the accomplishment of vigorous physical activity for the development of the disease. There is still no consensus regarding the involved factors in the etiology of ALS. In this way, new research about these etiologies are necessary, for a better approach of the patients, promoting preventive programs for the disease and improving the quality of life of the patients.

Introdução. A boa postura é o estado de equilíbrio musculoesqueléti­co que protege as estruturas de sustentação do corpo, podendo dimi­nuir a possibilidade de quedas e suas consequências. Queda é o deslo­camento não intencional do corpo com incapacidade de correção em tempo hábil, sua etiologia é bastante complexa e o sistema sensorial proprioceptivo tem apresentado fortes evidências como fator causal. Embora essas correlações tenham sido negligenciadas pela maioria dos profissionais de saúde, a correção do sistema sensorial propriocepti­vo, através de seus principais elementos: visual (convergência) e po­dal (valgo/varo), parece fundamental para a obtenção do equilíbrio postural. Objetivo. Discutir a influência visual e podal no equilíbrio morfoestático em idosos, bem como a prevenção de eventuais quedas. Método. Foi realizada uma busca nas bases de dados: Index Medicus; Biological Abstracts; Pub Med; Bireme; PEDro e Lilacs e seleciona­dos os artigos pertinentes ao tema. Discussão. A Posturologia Clínica visa resgatar o controle postural com estímulos mantidos em tempo hábil para promover mudanças no sistema sensorial e esquema cor­poral (neuroplasticidade), prevenindo quedas pela funcionalização do alinhamento e da estabilidade. Conclusão. As quedas ocorrem inde­pendente da idade e a regulação do eixo visuo-podal parece resgatar o equilíbrio postural e prevenir as quedas em idosos.

-This study aimed to elucidate electrophysiological and cortical mechanisms involved in anticipatory actions when individuals had to catch balls in free drop; specifically through quantitative electroencephalography (qEEG) alpha absolute power changes. The sample was composed for 23 health subjects, both sexes, with ages varying between 25 and 40 years, absence of mental and physical illness, right handed and don't make use of any psychoactive or psychotropic substance at the time of the study. The experiment consisted of a task of catching balls in free drop. The three-way ANOVA analysis demonstrated an interaction between moment and position factors in left parietal posterior cortex (PPC) (p=0.001). Through the experimental task employed, this area demonstrated a differentiated activity involving expectation, planning and preparedness in the ball's drop task.KEy words: absolute power, catch, qEEG, sensorimotor integration. Papel do córtex parietal posterior na realização de uma tarefa sensório-motoraResumo -o estudo tentou elucidar mecanismos eletrofisiológicos e corticais envolvidos em ações antecipatórias quando os sujeitos testados tiveram que apreender bolas em queda livre; especificamente através de mudanças na potência absoluta na banda alfa da eletrencefalografia quantitativa (EEGq). A amostra foi composta por 23 sujeitos sadios, ambos os sexos, idade entre variando entre 25 e 40 anos, sem comprometimento físico e mental, destros, e não fazer uso de nenhuma substância psicoativa ou psicotrópicos até o momento do estudo. o experimento consistiu de uma tarefa de apreensão de bolas em queda livre. A análise three-way ANOVA demonstrou uma interação entre os fatores momento e posição no córtex parietal posterior (CPP) esquerdo (p=0,001). Através da tarefa experimental empregada, esta área demonstrou uma atividade diferenciada envolvendo expectativa, planejamento e prontidão na tarefa de queda de bolas.PAlAvrAs-ChAvE: potência absoluta, apreender, EEGq, integração sensório-motora. The posterior parietal cortex (PPC) plays a crucial role in relation to motor planning based on sensory information. human functional magnetic resonance imaging (fMrI) experiments and electrophysiological recordings in nonhuman primates have shown that the PPC is neither sensory nor motor purely, but it is an area that encodes cognitive functions related to action 1,2 . The presence of sensory and motor specific representations together with high-level cognitive signals suggests that the PPC plays an important role for decision making related to action 2 .such representations are elementary components in the preparation and adjustment of a motor act and they take part in the integration among different and specialized centers in the final movement production 3 . This process occurs through sensorimotor integration, when sensory information is integrated by central nervous system to attend to motor programs.Catching an object is a complex movement which involves not only programming but also effective motor coordination. suc...

A child is reported with Behcet's disease who presented with skin and joint manifestations, oral ulcers, brainstem syndrome and neurogenic muscular atrophy. The neurogenic muscular atrophy was confirmed by electrophysiologic, histologic and histochemical studies. Electron microscopy of muscle showed a vasculopathy. The possible etiology of the muscle lesions is discussed. The relevant literature on muscle and peripheral nerve involvement in Behcet's disease is reviewed. It is proposed that neuromyopathy be added to the neurological manifestations of Behcet's disease. To our knowledge, this is the first case of neurogenic atrophy reported in Behcet's disease.