This article studies the questions of work, race and social differentiation among the artisan class of the New Kingdom of Granada towards the end of the colonial period, through the labor activities of Pedro Romero, an emblematic artisan of Cartagena de Indias. It analyzes the privileges this artisan achieved through a contrato de asentista with the Naval Station and the income he earned a a result, while at the same time comparing them with those obtained by other workers, in order to show the process of social differentiation that operated among certain sectors of the artisan class. Based on his relations with colonial institutions (defense systems), it concludes that Romero strengthened his condition of class determined by his standard of living, and thus differentiated himself from his fellow artisans, which also allowed him to offset the influence of his racial condition. The article also concludes that during the second half of the 18th century, the relations between artisans and colonial institutions were transformed, due to the needs of military defense.

Background The pathogenetical association between autoimmunity and cancer has been previously described. Objectives In this study we aimed to better describe the complex relationship between autoimmunity and neoplastic diseases in a retrospective cohort from our outpatient Immunorheumatology clinic. In particular we aimed to identify those immune conditions the diagnosis of which is associated to an increased risk of being diagnosed for a cancer within 2 years before and after the rheumatological syndrome onset. Methods We evaluated 3975 clinical records from 1st January 2005 to 30th November 2012. We used non immune-mediated conditions (fibromyalgia and osteoarthritis) as controls. We included in the analysis only patients with at least 2 years of follow-up. Results We reported 144/1750 cases of cancer in the general population (8.2% [6.91 – 9.49]), 41/702 of which (5.9% [4.16–7.64]) in control group. The prevalence of cancer was increased in patients affected by Sjogren's Syndrome (18.3% [8.52–28.08]; OR 3.62 [1.75–7.48]), Dermatomyositis/Polimyositis (42.9% [6.24–79.56]; 12.09 [2.65–55.8]), Vasculitis (18.8% [9.23–28.37]; 3.70 [1.81–7.52]) and Polimyalgia Rheumatica (24.0% [15.63–32.37]; 5.09 [2.92–8.88]). Logistic regression identified all these diagnosis, age >65 and male sex as independent risk factors for neoplastic disease. Conclusions DM/PM, vasculitis and PMR show an increased risk of neoplasms during the whole observation period and a high prevalence of symptoms remission after cancer treatment as expected for a paraneoplastic manifestation; vice versa Sjogren's Syndrome seems to be more likely a causal factor for cancer (in particular lymphoma), since the risk is increased exclusively in the prospective follow-up and the treatment of cancer is not associated to a remission of rheumatological symptoms. Disclosure of Interest None declared DOI 10.1136/annrheumdis-2014-eular.1955