Objective To correlate the immunohistochemically of decreased E-cadherin expression for the long-term or recurrence-free survival of patients, using a threshold detected loss of E-cadherin expression with patient age, clinical and biological variables, and to investigate value of 40% for the relative amount of positively stained tumour cells, or for any other threshold value the prognostic value of these variables for the relapsefree and overall survival of patients with diCerent calculated (25%, 60% or 75%). However, comparing a follow-up of 16 months in patients with <40% stages of newly diagnosed prostate cancer. Patients and methods Sixty-seven patients (median age positivity and 46 months in patients with Á40% positivity, those patients retaining E-cadherin 63 years, range 48-78) undergoing radical prostatectomy for the treatment of primary prostate cancer expression had a significantly longer recurrence-free interval after radical prostatectomy (P<0.01). were assessed to determine whether age, tumour stage, histological grading, serum levels of prostate specific Conclusion The value of E-cadherin expression as an additional independent prognostic variable for patients antigen and prostatic acid phosphatase, regional lymph node status and E-cadherin expression were with primary prostate cancer is questionable. Keywords E-cadherin, expression, prostate cancer, radprognostic factors for relapse-free and overall survival. Results With a median (range) follow-up of 54 (3-193) ical prostatectomy, clinical prognosis months, there was no independent prognostic value brane 120 kDa glycoprotein belonging to the group of