Introduction: Since disability and its associated problems are permanent, it can have a profound effect on the mental health and resilience of parents. Aim:The aime of the present study was to compare the resilience and mental health in parents of people with and without mobility impairment. Method:The statistical population of this causal-comparative research included all parents of people with and without mobility impairment in Shiraz city, whose children have 10-18years. The sample were 120 parents of children with mobility impairment was recruited by purposeful sampling and 120 parents of children without mobility impairment were selected through a multistage random sampling method from Shiraz city schools. The Connor-Davidson Resilience Scale (CD-RTS9) and mental health scale (GHQ28) was utilized for Collecting data. Data were analyzed by using Two-way ANOVA and MANOVA.Results: Analysis of the findings showed resilience and mental health (physical symptoms, depressive symptoms, social functioning and anxiety) of parents of people with mobility impairment were significantly lower than parents of people without mobility impairment (P<0.001). Conclusion:According to this finding it is suggested to design and implement appropriate intervention programs in order to improve mental health and resilienc in parents of children with mobility impairment.