The f u e l development program a t t h e MTR has sought t o develop improved. economical, l o n g-l i f e f u e l assemblies through a comprehensive s t u d y of v a r i o u s f u e l compositions, enrichments, claddings, burnable poisons, f u e l and poison d i s t r i b u t i o n s , and f u e l element geometry optimizat,ion. 53 53 53 64 75 75 88 88 93 93 93 94 102 102 102 *. a Reverse Side o f P l a t e Shown i n Figure 10. e Edge View of P l a t e Shown i n Figures 10 and 11 Edge V i e w of' P l a t e i n Figures 10 Through 12 A f t e r Being Sectioned and Mounted f o r Metall u r g i c a l Exm,ination. @-*. a * * With I r r a d i a t i o n (22.7 w t $ U02). a. Changes i n Microstructure of Oxide Fuel Core 39 41 .-9-LIST OF FIGURES (Cont ' d)

A putative amethystic product was studied in two cohorts of human subjects. The amethystic product (Sobrietol) was applied according to the manufacturer's instructions while control subjects received water in place of the Sobrietol solution. The two cohorts were challenged with 1.2 ml/lb and 1.4 ml/lb of 80 proof liquor, respectively, with subsequent breath alcohol (BrAC) measurement. In cohort 1, Sobrietol reduced the area under the BrAC curve (AUC) by 15.1% (p = 0.003) relative to controls; in cohort 2 the AUC was reduced by 12.5% (p = 0.011) relative to controls. It appears that the amethystic product Sobrietol can eliminate significantly greater ethanol than ethanol eliminated by similar controls.