Population growth has been evoked both as a causal factor and consequence of the transition to agriculture. The use of radiocarbon (14C) dates as proxies for population allows for reevaluations of population as a variable in the transition to agriculture. In Korea, numerous rescue excavations during recent decades have offered a wealth of 14C data for this application. A summed probability distribution (SPD) of 14C dates is investigated to reconstruct population trends preceding and following adoptions of food production in prehistoric Korea. Important cultivars were introduced to Korea in two episodes: millets during the Chulmun Period (ca. 6000–1500 BCE) and rice during the Mumun Period (ca. 1500–300 BCE). The SPD suggests that while millet production had little impact on Chulmun populations, a prominent surge in population appears to have followed the introduction of rice. The case in prehistoric Korea demonstrates that the adoption of food production does not lead inevitably towards sustained population growth. Furthermore, the data suggest that the transition towards intensive agriculture need not occur under conditions of population pressure resulting from population growth. Rather, intensive rice farming in prehistoric Korea began during a period of population stagnation.

Glucose-6-phosphate dehydrogenase (G6PD) protects erythrocytes from oxidative stress and hemolysis; G6PD deficiency is the most prevalent enzymopathy. The United States military routinely performs tests to prevent exposing G6PD-deficient personnel to antimalarial drugs that might cause life-threatening hemolytic reactions. In addition, G6PD is a key determinant of vascular function, and its deficiency can lead to impaired nitric oxide production and greater vascular oxidant stress-precursors to atherosclerosis and cardiovascular disease. Using military medical records, we performed a retrospective, cross-sectional study to investigate whether deficient G6PD levels are associated with a higher prevalence of cardiovascular disease than are normal levels, and, if so, whether the relationship is independent of accepted cardiovascular risk factors. We analyzed the medical records of 737 individuals who had deficient G6PD levels and 16,601 who had normal levels. Everyone had been screened at U.S. military medical centers from August 2004 through December 2007. We evaluated our dependent variable (composite cardiovascular disease) at the individual level, and performed binary logistic regression of our independent variable (G6PD status) and control variables (modifiable cardiovascular risk factors). The adjusted odds ratio of 1.396 (95% CI, 1.044-1.867; <0.05) indicated that G6PD-deficient individuals have 39.6% greater odds of developing cardiovascular disease than do those with normal levels. Early intervention may reduce the incidence of cardiovascular disease in military personnel and civilians who have deficient G6DP levels.

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